Clinical Profile, Etiology, and Treatment of Chronic Pancreatitis in North American Women: Analysis of a Large Multicenter Cohort

Joseph Romagnuolo, Jyothsna Talluri, Elizabeth Kennard, Bimaljit S. Sandhu, Stuart Sherman, Gregory A. Cote, Samer Al-Kaade, Timothy B. Gardner, Andres Gelrud, Michele D. Lewis, Christopher E. Forsmark, Nalini M. Guda, Darwin L. Conwell, Peter A. Banks, Thiruvengadam Muniraj, Stephen R. Wisniewski, Ye Tian, C. Mel Wilcox, Michelle A. Anderson, Randall E. BrandAdam Slivka, David C. Whitcomb, Dhiraj Yadav

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Objective Historically, chronic pancreatitis (CP) was considered a disease of alcoholic males, but recent data suggest its etiology to be complex. To better understand CP in women, we compared data on women and men with CP in a large, prospectively ascertained multicenter US cohort. Methods Patients with CP enrolled in the NAPS2 Continuation and Validation study were studied. Information on demographics, etiology, risk factors, phenotype, and treatment(s) used was obtained from detailed questionnaires completed by the patients and physicians. Results Of 521 cases, 45% were women. Women were significantly (P < 0.05) less likely to have alcohol etiology (30% vs 58.5%) and more likely to have nonalcoholic etiologies (idiopathic, 32% vs 18%; obstructive, 12% vs 2.4%; genetic, 12.8% vs 7.3%). Demographics, pain experience, morphologic findings, exocrine and endocrine insufficiency, CP-related disability, and use of medical therapies were mostly similar in both sexes. Sphincterotomy (biliary, 33% vs 24%; pancreatic, 38% vs 28%; P < 0.05) was performed more frequently in women, whereas cyst/pseudocyst operations were more common in men (6.6 vs 2.6%, P = 0.02). Conclusions Most CP cases in women are from nonalcoholic etiologies. In contrast to many other chronic diseases, clinical phenotype of CP is determined by the disease and is independent of sex.

Original languageEnglish
Pages (from-to)934-940
Number of pages7
Issue number7
StatePublished - Aug 1 2016

Bibliographical note

Funding Information:
This study was supported by R01DK061451 (D.C.W.), R01 DK077906 (D.Y.), and UL1 RR024153 and UL1TR000005 (PI, Steven E Reis, MD), ASGE Senior Investigator Mentoring Award (J.R.).

Publisher Copyright:
© 2016 Wolters Kluwer Health, Inc. All rights reserved.


  • demographics
  • evaluation
  • pancreatitis
  • therapy
  • women

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology


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