Clinical, radiographic, and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12-month multicenter clinical trial

Ana Lívia Fileto Mazzonetto, Renato Corrêa Viana Casarin, Mauro Pedrine Santamaria, Naira Maria Rebelatto Bechara Andere, Cássia Fernandes Araújo, Rafaela Videira Clima da Silva, Javier Eduardo Vivanco Purisaca, Enilson Antonio Sallum, Antonio Wilson Sallum

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: The aim of this study was to evaluate the clinical, radiographic and patient-centered results of enamel matrix derivative (EMD) therapy in intrabony defects in aggressive periodontitis (AgP) patients and compare them with those in chronic periodontitis (CP) patients. Methods: Sixty intrabony defects in AgP and CP patients associated with ≥ 6 mm residual probing pocket depth (PPD) were included and randomly assigned to one of three groups: AgP+CS (conservative surgery) (n = 20); AgP+CS/EMD (n = 20); CP+CS/EMD (n = 20). Clinical parameters were measured at baseline and after 6 and 12 months. Defect resolution (DR) and bone filling (BF) were used for radiographic analysis. The quality of life was recorded at baseline and 6 months using OHIP-14 and VAS scale in the early post-therapy period. Results: PPD and relative clinical attachment level (rCAL) improved for all groups during follow-up (P ≤ 0.05), and AgP+CS/EMD presented a higher rCAL gain (2.4 ± 1.0 mm) when compared to AgP control patients (1.6 ± 1.6 mm, P ≤ 0.05) after 12 months. No difference was observed between AgP+CS/EMD and CP+CS/EMD groups (P > 0.05). No radiographic differences were observed among groups at any time point (P > 0.05). All the groups reported a positive impact on OHIP-14 total score, without differences among them. Conclusions: EMD therapy of intrabony defects promotes additional benefits in AgP patients, presenting a similar regeneration rate compared to CP patients, and has proven to be a viable therapy for the treatment of individuals with AgP.

Original languageEnglish
Pages (from-to)995-1006
Number of pages12
JournalJournal of Periodontology
Volume92
Issue number7
DOIs
StatePublished - Jul 2021

Bibliographical note

Funding Information:
This study was supported by the São Paulo Research Foundation (FAPESP), São Paulo, SP, Brazil (process 2015/19731‐0) and Coordination of Improvement of Higher Education Personnel (CAPES), Brazil (financing code 001).

Publisher Copyright:
© 2020 American Academy of Periodontology

Keywords

  • aggressive periodontitis
  • alveolar bone loss
  • chronic periodontitis
  • enamel matrix proteins

ASJC Scopus subject areas

  • Periodontics

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