TY - JOUR
T1 - Clinical trial of 252Cf neutron brachytherapy vs. conventional radiotherapy for advanced cervical cancer
AU - Maruyama, Y.
AU - Kryscio, R.
AU - Van Nagell, J. R.
AU - Yoneda, J.
AU - Donaldson, E.
AU - Hanson, M.
AU - Beach, J. L.
AU - Feola, J. M.
AU - Martin, A.
AU - Parker, C.
PY - 1985/8
Y1 - 1985/8
N2 - 252Cf, a neutron emitting radioactive transplutonium isotope, was tested for its efficacy against advanced bulky Stage III-IV cancers of the cervix in a clinical trial at the University of Kentucky Medical Center. Eighty-two patients were treated during 1976-1979 and followed for 5-year survival and tumor control. Three different treatment methods went on sequentially and concurrently, that is, (a) conventional whole pelvis photon with delayed 137Cs implants, (b) conventional photon therapy with delayed 252Cf implants, and (c) 252Cf implants ("early") preceding photon therapy. There were 12% 5-year survival for Stage IIIB cancers by conventional therapy, and 15% by delayed Z5ZCf implant therapy. For early Z5ZCf implant therapy there were 54% 5-year survivals with 4% complications and 65% 5-year local control, but distant metastases became a prominent delayed failure pattern.
AB - 252Cf, a neutron emitting radioactive transplutonium isotope, was tested for its efficacy against advanced bulky Stage III-IV cancers of the cervix in a clinical trial at the University of Kentucky Medical Center. Eighty-two patients were treated during 1976-1979 and followed for 5-year survival and tumor control. Three different treatment methods went on sequentially and concurrently, that is, (a) conventional whole pelvis photon with delayed 137Cs implants, (b) conventional photon therapy with delayed 252Cf implants, and (c) 252Cf implants ("early") preceding photon therapy. There were 12% 5-year survival for Stage IIIB cancers by conventional therapy, and 15% by delayed Z5ZCf implant therapy. For early Z5ZCf implant therapy there were 54% 5-year survivals with 4% complications and 65% 5-year local control, but distant metastases became a prominent delayed failure pattern.
KW - 5 year survival
KW - Cf-252
KW - Comparison efficacy
KW - Conventional photon
KW - Schedule
KW - advanced cervical cancer
KW - neutron brachytherapy
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U2 - 10.1016/0360-3016(85)90335-9
DO - 10.1016/0360-3016(85)90335-9
M3 - Article
C2 - 4019271
AN - SCOPUS:0021893544
SN - 0360-3016
VL - 11
SP - 1475
EP - 1482
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 8
ER -