Clinically relevant interactions between atypical antipsychotics and anti-infective agents

Edoardo Spina, Maria Antonietta Barbieri, Giuseppe Cicala, Jose de Leon

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or pharmacodynamic (PD) DIs. PubMed searches were conducted for each of the atypical antipsychotics and most commonly used anti-infective agents (13 atypical antipsychotics by 61 anti-infective agents/classes leading to 793 individual searches). Additional relevant articles were obtained from citations and from prior review articles written by the authors. Based on prior DI articles and our current understanding of PK and PD mechanism, we developed tables with practical recommendations for clinicians for: antibiotic DIs, antitubercular DIs, antifungal DIs, antiviral DIs, and other anti-infective DIs. Another table reflects that in clinical practice, DIs between atypical antipsychotics and anti-infective agents occur in patients also suffering an infection that may also influence the PK and PD mechanisms of both drugs (the atypical antipsychotic and the anti-infective agent(s)). These tables reflect the currently available literature and our current knowledge of the field and will need to be updated as new DI information becomes available.

Original languageEnglish
Article number439
Pages (from-to)1-33
Number of pages33
Issue number12
StatePublished - Dec 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • Antibacterial agents
  • Antibiotics
  • Antifungal agents
  • Antimalarials
  • Antipsychotic agents
  • Antitubercular
  • Antiviral agents
  • Drug interactions
  • Pharmacokinetics
  • Pharmacology

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery


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