CncC/Maf-mediated xenobiotic response pathway in insects

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41 Scopus citations


Insects have evolved resistance to almost all insecticides developed for their control. Multiple mechanisms of resistance, including enhanced metabolism and excretion of insecticides, target-site insensitivity, reduced penetration of insecticides, and avoidance behavior, have been reported. The genes coding for proteins involved in resistance have been identified in numerous insects. The enzymes and transporters required for all three phases of insecticide metabolism and excretion including cytochrome P450 monooxygenases, glutathione S-transferases, UDP-glucuronosyltransferases, carboxylesterases, and ATP-binding cassette transmembrane transporters have been identified. Recent research in multiple insect species identified CNC-bZIP transcription factor superfamily members as regulators of genes coding for enzymes and transporters involved in insecticide metabolic resistance. The information on the pathway including reactive oxygen species, cap “n” collar isoform-C, and its heterodimer partner, muscle aponeurosis fibromatosis transcription factors involved in overexpression of enzymes and transporters involved insecticide resistance will be summarized.

Original languageEnglish
Article numbere21674
JournalArchives of Insect Biochemistry and Physiology
Issue number2
StatePublished - Jun 1 2020

Bibliographical note

Funding Information:
The work in Palli laboratory is supported by grants from the National Institutes of Health (GM070559‐14 and 1R21AI131427‐01), the National Science Foundation (Industry/University Cooperative Research Centers, the Center for Arthropod Management Technologies under Grant IIP‐1821936), Agriculture and Food Research Initiative Competitive Grant No. 2019‐67013‐29351 and the National Institute of Food and Agriculture, US Department of Agriculture (under HATCH Project 2353057000). The authors declare that there are no conflicts of interest.

Publisher Copyright:
© 2020 Wiley Periodicals, Inc.


  • CncC
  • Maf
  • P450
  • ROS
  • xenobiotic response

ASJC Scopus subject areas

  • Physiology
  • Biochemistry
  • Insect Science


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