CNS monoamine levels and motoric behaviors in the hotfoot ataxic mutant

Laura J. Draski, Donald J. Nash, Greg A. Gerhardt

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Mice that were homozygous recessive for the single-gene mutation, hotfoot, showed profound and progressive motor disturbances in an open field after approximately the 4th postnatal week. Studies were undertaken to examine the role of the monoaminergic system in the behavioral and developmental expression of this neurological mutation. Relative to controls, 10- and 30-day-old hotfoot mice demonstrated a significantly attenuated response to the stimulating locomotor effects of amphetamine while adult hotfoot mice were motorically unaffected by amphetamine administration. 30-day-old and adult hotfoot mice also were hypothermic relative to phenotypically normal mice after amphetamine administration. Examination of monoamine levels and turnover revealed that hotfoot mice had significantly greater concentrations of norepinephrine associated with lower turnover in cerebellum and greater levels of serotonin in cerebellum and striatum, relative to phenotypic controls. In addition, mice born and raised by hotfoot dams demonstrated neurochemical alterations regardless of genotype. Both the neurochemical data and the developmental response to the general catecholamine agonist, amphetamine, suggest that the monaminergic neurotransmitter system may be altered as a consequence of the hotfoot mutation.

Original languageEnglish
Pages (from-to)69-77
Number of pages9
JournalBrain Research
Volume645
Issue number1-2
DOIs
StatePublished - May 9 1994

Keywords

  • Amphetamine
  • Ataxia
  • Development
  • Hotfoot
  • Monoamine
  • Motor behavior
  • Neurological mutation
  • Thermoregulation

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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