Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth

Lixiang Gu; Xingcong Ren; Chrispus Ngule; Xiaofang Xiong; Jianxun Song; Zhiguo Li; Jin Ming Yang

doi:10.3390/biomedicines11082221

Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth

Lixiang Gu, Xingcong Ren, Chrispus Ngule, Xiaofang Xiong, Jianxun Song, Zhiguo Li, Jin Ming Yang

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Nucleus-accumbens-associated protein-1 (NAC1) is a cancer-related transcriptional factor encoded by the NACC1 gene, which is amplified and overexpressed in various human cancers and has been appreciated as one of the top potential cancer driver genes. NAC1 has therefore been explored as a potential therapeutic target for managing malignant tumors. Here, we show that NAC1 is a negative regulator of NF-κB signaling, and NAC1 depletion enhances the level of the nuclear NF-κB in human melanoma. Furthermore, the inhibition of NF-κB signaling significantly potentiates the antineoplastic activity of the NAC1 inhibition in both the cultured melanoma cells and xenograft tumors. This study identifies a novel NAC1-NF-κB signaling axis in melanoma, offering a promising new therapeutic option to treat melanoma.

Original language	English
Article number	2221
Journal	Biomedicines
Volume	11
Issue number	8
DOIs	https://doi.org/10.3390/biomedicines11082221
State	Published - Aug 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Funding

This research was funded by [National Institutes of Health] grant number [RO1CA266579] And [National Institutes of Health] grant number [R01CA221867].

Funders	Funder number
National Institutes of Health (NIH)	R01CA221867, RO1CA266579

Keywords

NAC1
melanoma

ASJC Scopus subject areas

Medicine (miscellaneous)
General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/biomedicines11082221

Cite this

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title = "Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth",

abstract = "Nucleus-accumbens-associated protein-1 (NAC1) is a cancer-related transcriptional factor encoded by the NACC1 gene, which is amplified and overexpressed in various human cancers and has been appreciated as one of the top potential cancer driver genes. NAC1 has therefore been explored as a potential therapeutic target for managing malignant tumors. Here, we show that NAC1 is a negative regulator of NF-κB signaling, and NAC1 depletion enhances the level of the nuclear NF-κB in human melanoma. Furthermore, the inhibition of NF-κB signaling significantly potentiates the antineoplastic activity of the NAC1 inhibition in both the cultured melanoma cells and xenograft tumors. This study identifies a novel NAC1-NF-κB signaling axis in melanoma, offering a promising new therapeutic option to treat melanoma.",

keywords = "NAC1, melanoma",

author = "Lixiang Gu and Xingcong Ren and Chrispus Ngule and Xiaofang Xiong and Jianxun Song and Zhiguo Li and Yang, \{Jin Ming\}",

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month = aug,

doi = "10.3390/biomedicines11082221",

language = "English",

volume = "11",

number = "8",

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T1 - Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth

AU - Gu, Lixiang

AU - Ren, Xingcong

AU - Ngule, Chrispus

AU - Xiong, Xiaofang

AU - Song, Jianxun

AU - Li, Zhiguo

AU - Yang, Jin Ming

PY - 2023/8

Y1 - 2023/8

N2 - Nucleus-accumbens-associated protein-1 (NAC1) is a cancer-related transcriptional factor encoded by the NACC1 gene, which is amplified and overexpressed in various human cancers and has been appreciated as one of the top potential cancer driver genes. NAC1 has therefore been explored as a potential therapeutic target for managing malignant tumors. Here, we show that NAC1 is a negative regulator of NF-κB signaling, and NAC1 depletion enhances the level of the nuclear NF-κB in human melanoma. Furthermore, the inhibition of NF-κB signaling significantly potentiates the antineoplastic activity of the NAC1 inhibition in both the cultured melanoma cells and xenograft tumors. This study identifies a novel NAC1-NF-κB signaling axis in melanoma, offering a promising new therapeutic option to treat melanoma.

AB - Nucleus-accumbens-associated protein-1 (NAC1) is a cancer-related transcriptional factor encoded by the NACC1 gene, which is amplified and overexpressed in various human cancers and has been appreciated as one of the top potential cancer driver genes. NAC1 has therefore been explored as a potential therapeutic target for managing malignant tumors. Here, we show that NAC1 is a negative regulator of NF-κB signaling, and NAC1 depletion enhances the level of the nuclear NF-κB in human melanoma. Furthermore, the inhibition of NF-κB signaling significantly potentiates the antineoplastic activity of the NAC1 inhibition in both the cultured melanoma cells and xenograft tumors. This study identifies a novel NAC1-NF-κB signaling axis in melanoma, offering a promising new therapeutic option to treat melanoma.

KW - NAC1

KW - melanoma

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U2 - 10.3390/biomedicines11082221

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M3 - Article

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JO - Biomedicines

JF - Biomedicines

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ER -

Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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