Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity

Sheng Tong, Sijian Hou, Zhilan Zheng, Jun Zhou, Gang Bao

Research output: Contribution to journalArticlepeer-review

383 Scopus citations

Abstract

We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T2 relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T2 relaxivity of 385 s-1 mM-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.

Original languageEnglish
Pages (from-to)4607-4613
Number of pages7
JournalNano Letters
Volume10
Issue number11
DOIs
StatePublished - Nov 10 2010

Keywords

  • MRI contrast agent
  • SPIO
  • molecular imaging
  • nuclear relaxation

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering

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