Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity

Sheng Tong; Sijian Hou; Zhilan Zheng; Jun Zhou; Gang Bao

doi:10.1021/nl102623x

Coating optimization of superparamagnetic iron oxide nanoparticles for high T₂ relaxivity

Sheng Tong
, Sijian Hou
, Zhilan Zheng
, Jun Zhou
, Gang Bao

Research output: Contribution to journal › Article › peer-review

421 Scopus citations

Abstract

We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T₂ relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T₂ relaxivity of 385 s^-1 mM^-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.

Original language	English
Pages (from-to)	4607-4613
Number of pages	7
Journal	Nano Letters
Volume	10
Issue number	11
DOIs	https://doi.org/10.1021/nl102623x
State	Published - Nov 10 2010

Funding

Funders	Funder number
National Childhood Cancer Registry – National Cancer Institute	U54CA119338
National Childhood Cancer Registry – National Cancer Institute

Keywords

MRI contrast agent
SPIO
molecular imaging
nuclear relaxation

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

Access to Document

10.1021/nl102623x

Cite this

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abstract = "We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T2 relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T2 relaxivity of 385 s-1 mM-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.",

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AU - Tong, Sheng

AU - Hou, Sijian

AU - Zheng, Zhilan

AU - Zhou, Jun

AU - Bao, Gang

PY - 2010/11/10

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N2 - We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T2 relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T2 relaxivity of 385 s-1 mM-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.

AB - We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T2 relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T2 relaxivity of 385 s-1 mM-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.

KW - MRI contrast agent

KW - SPIO

KW - molecular imaging

KW - nuclear relaxation

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