Abstract
The research community is intent on harnessing increasingly complex biological building blocks. At present, cells represent a highly functional component for integration into higher order systems. In this review, we discuss the current application space for cellular coating technologies and emphasize the relationship between the target application and coating design. We also discuss how the cell and the coating interact in common analytical techniques, and where caution must be exercised in the interpretation of results. Finally, we look ahead at emerging application areas that are ideal for innovation in cellular coatings. In all, cellular coatings leverage the machinery unique to specific cell types, and the opportunities derived from these hybrid assemblies have yet to be fully realized.
| Original language | English |
|---|---|
| Article number | 5 |
| Journal | Journal of Biological Engineering |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 17 2019 |
Bibliographical note
Funding Information:This work was partially supported by R01 HL127682–01 and the National Science Foundation under Awards CBET-1351531 and CBET-1758210. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The views expressed in this manuscript do not represent the views of the NIH, NSF, or any other government agency or official.
Publisher Copyright:
© 2019 The Author(s).
Keywords
- Cell therapy
- Cellular coatings
- Coatings
- Mammalian cells
- Polymers
ASJC Scopus subject areas
- Environmental Engineering
- Biomedical Engineering
- Molecular Biology
- Cell Biology