TY - JOUR
T1 - Coatings on mammalian cells
T2 - Interfacing cells with their environment 06 Biological Sciences 0601 Biochemistry and Cell Biology
AU - Davis, Kara A.
AU - Wu, Pei Jung
AU - Cahall, Calvin F.
AU - Li, Cong
AU - Gottipati, Anuhya
AU - Berron, Brad J.
N1 - Publisher Copyright:
© 2019 The Author(s).
PY - 2019/1/17
Y1 - 2019/1/17
N2 - The research community is intent on harnessing increasingly complex biological building blocks. At present, cells represent a highly functional component for integration into higher order systems. In this review, we discuss the current application space for cellular coating technologies and emphasize the relationship between the target application and coating design. We also discuss how the cell and the coating interact in common analytical techniques, and where caution must be exercised in the interpretation of results. Finally, we look ahead at emerging application areas that are ideal for innovation in cellular coatings. In all, cellular coatings leverage the machinery unique to specific cell types, and the opportunities derived from these hybrid assemblies have yet to be fully realized.
AB - The research community is intent on harnessing increasingly complex biological building blocks. At present, cells represent a highly functional component for integration into higher order systems. In this review, we discuss the current application space for cellular coating technologies and emphasize the relationship between the target application and coating design. We also discuss how the cell and the coating interact in common analytical techniques, and where caution must be exercised in the interpretation of results. Finally, we look ahead at emerging application areas that are ideal for innovation in cellular coatings. In all, cellular coatings leverage the machinery unique to specific cell types, and the opportunities derived from these hybrid assemblies have yet to be fully realized.
KW - Cell therapy
KW - Cellular coatings
KW - Coatings
KW - Mammalian cells
KW - Polymers
UR - http://www.scopus.com/inward/record.url?scp=85060171597&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060171597&partnerID=8YFLogxK
U2 - 10.1186/s13036-018-0131-6
DO - 10.1186/s13036-018-0131-6
M3 - Review article
AN - SCOPUS:85060171597
SN - 1754-1611
VL - 13
JO - Journal of Biological Engineering
JF - Journal of Biological Engineering
IS - 1
M1 - 5
ER -