Coaxial electrohydrodynamic atomization process for production of polymeric composite microspheres

Qingxing Xu; Hao Qin; Zhenyuan Yin; Jinsong Hua; Daniel W. Pack; Chi Hwa Wang

doi:10.1016/j.ces.2013.09.020

Coaxial electrohydrodynamic atomization process for production of polymeric composite microspheres

Qingxing Xu, Hao Qin, Zhenyuan Yin, Jinsong Hua, Daniel W. Pack, Chi Hwa Wang

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Polymeric composite microspheres consisting of a poly( d,. l-lactic-co-glycolic acid) (PLGA) core surrounded by a poly( d,. l-lactic acid) (PDLLA) shell layer were successfully fabricated by coaxial electrohydrodynamic atomization (CEHDA) process. Process conditions, including nozzle voltage and polymer solution flow rates, as well as solution parameters, such as polymer concentrations, were investigated to ensure the formation of composite microspheres with a doxorubicin-loaded PLGA core surrounded by a relatively drug-free PDLLA shell layer. Various microsphere formulations were fabricated and characterized in terms of their drug distribution, encapsulation efficiency and in vitro release. Numerical simulation of CEHDA process was performed based on a computational fluid dynamics (CFD) model in Fluent by employing the process conditions and fluid properties used in the experiments. The simulation results were compared with the experimental work to illustrate the capability of the CFD model to predict the production of consistent compound droplets, and hence, the expected core-shell structured microspheres.

Original language	English
Pages (from-to)	330-346
Number of pages	17
Journal	Chemical Engineering Science
Volume	104
DOIs	https://doi.org/10.1016/j.ces.2013.09.020
State	Published - Dec 18 2013

Bibliographical note

Funding Information:
The authors acknowledge the funding support from the National Medical Research Council (NMRC), Singapore and National Institutes of Health (NIH), USA under the grant numbers NMRC EDG11may084 and 1R01EB005181 , respectively. Qingxing Xu acknowledges the scholarship support from Agency for Science, Technology and Research (A ⁎ STAR), Singapore for NUS-UIUC Joint Ph.D. Program.

Keywords

Coaxial electrohydrodynamic atomization
Core-shell structured microspheres
Mathematical modeling
Multiphase flow
Polymers
Simulation

ASJC Scopus subject areas

Chemistry (all)
Chemical Engineering (all)
Industrial and Manufacturing Engineering

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title = "Coaxial electrohydrodynamic atomization process for production of polymeric composite microspheres",

abstract = "Polymeric composite microspheres consisting of a poly( d,. l-lactic-co-glycolic acid) (PLGA) core surrounded by a poly( d,. l-lactic acid) (PDLLA) shell layer were successfully fabricated by coaxial electrohydrodynamic atomization (CEHDA) process. Process conditions, including nozzle voltage and polymer solution flow rates, as well as solution parameters, such as polymer concentrations, were investigated to ensure the formation of composite microspheres with a doxorubicin-loaded PLGA core surrounded by a relatively drug-free PDLLA shell layer. Various microsphere formulations were fabricated and characterized in terms of their drug distribution, encapsulation efficiency and in vitro release. Numerical simulation of CEHDA process was performed based on a computational fluid dynamics (CFD) model in Fluent by employing the process conditions and fluid properties used in the experiments. The simulation results were compared with the experimental work to illustrate the capability of the CFD model to predict the production of consistent compound droplets, and hence, the expected core-shell structured microspheres.",

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author = "Qingxing Xu and Hao Qin and Zhenyuan Yin and Jinsong Hua and Pack, {Daniel W.} and Wang, {Chi Hwa}",

note = "Funding Information: The authors acknowledge the funding support from the National Medical Research Council (NMRC), Singapore and National Institutes of Health (NIH), USA under the grant numbers NMRC EDG11may084 and 1R01EB005181 , respectively. Qingxing Xu acknowledges the scholarship support from Agency for Science, Technology and Research (A ⁎ STAR), Singapore for NUS-UIUC Joint Ph.D. Program. ",

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AU - Xu, Qingxing

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AU - Yin, Zhenyuan

AU - Hua, Jinsong

AU - Pack, Daniel W.

AU - Wang, Chi Hwa

N1 - Funding Information: The authors acknowledge the funding support from the National Medical Research Council (NMRC), Singapore and National Institutes of Health (NIH), USA under the grant numbers NMRC EDG11may084 and 1R01EB005181 , respectively. Qingxing Xu acknowledges the scholarship support from Agency for Science, Technology and Research (A ⁎ STAR), Singapore for NUS-UIUC Joint Ph.D. Program.

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N2 - Polymeric composite microspheres consisting of a poly( d,. l-lactic-co-glycolic acid) (PLGA) core surrounded by a poly( d,. l-lactic acid) (PDLLA) shell layer were successfully fabricated by coaxial electrohydrodynamic atomization (CEHDA) process. Process conditions, including nozzle voltage and polymer solution flow rates, as well as solution parameters, such as polymer concentrations, were investigated to ensure the formation of composite microspheres with a doxorubicin-loaded PLGA core surrounded by a relatively drug-free PDLLA shell layer. Various microsphere formulations were fabricated and characterized in terms of their drug distribution, encapsulation efficiency and in vitro release. Numerical simulation of CEHDA process was performed based on a computational fluid dynamics (CFD) model in Fluent by employing the process conditions and fluid properties used in the experiments. The simulation results were compared with the experimental work to illustrate the capability of the CFD model to predict the production of consistent compound droplets, and hence, the expected core-shell structured microspheres.

AB - Polymeric composite microspheres consisting of a poly( d,. l-lactic-co-glycolic acid) (PLGA) core surrounded by a poly( d,. l-lactic acid) (PDLLA) shell layer were successfully fabricated by coaxial electrohydrodynamic atomization (CEHDA) process. Process conditions, including nozzle voltage and polymer solution flow rates, as well as solution parameters, such as polymer concentrations, were investigated to ensure the formation of composite microspheres with a doxorubicin-loaded PLGA core surrounded by a relatively drug-free PDLLA shell layer. Various microsphere formulations were fabricated and characterized in terms of their drug distribution, encapsulation efficiency and in vitro release. Numerical simulation of CEHDA process was performed based on a computational fluid dynamics (CFD) model in Fluent by employing the process conditions and fluid properties used in the experiments. The simulation results were compared with the experimental work to illustrate the capability of the CFD model to predict the production of consistent compound droplets, and hence, the expected core-shell structured microspheres.

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KW - Mathematical modeling

KW - Multiphase flow

KW - Polymers

KW - Simulation

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Coaxial electrohydrodynamic atomization process for production of polymeric composite microspheres

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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