Polymeric composite microspheres consisting of a poly( d,. l-lactic-co-glycolic acid) (PLGA) core surrounded by a poly( d,. l-lactic acid) (PDLLA) shell layer were successfully fabricated by coaxial electrohydrodynamic atomization (CEHDA) process. Process conditions, including nozzle voltage and polymer solution flow rates, as well as solution parameters, such as polymer concentrations, were investigated to ensure the formation of composite microspheres with a doxorubicin-loaded PLGA core surrounded by a relatively drug-free PDLLA shell layer. Various microsphere formulations were fabricated and characterized in terms of their drug distribution, encapsulation efficiency and in vitro release. Numerical simulation of CEHDA process was performed based on a computational fluid dynamics (CFD) model in Fluent by employing the process conditions and fluid properties used in the experiments. The simulation results were compared with the experimental work to illustrate the capability of the CFD model to predict the production of consistent compound droplets, and hence, the expected core-shell structured microspheres.
|Number of pages||17|
|Journal||Chemical Engineering Science|
|State||Published - Dec 18 2013|
Bibliographical noteFunding Information:
The authors acknowledge the funding support from the National Medical Research Council (NMRC), Singapore and National Institutes of Health (NIH), USA under the grant numbers NMRC EDG11may084 and 1R01EB005181 , respectively. Qingxing Xu acknowledges the scholarship support from Agency for Science, Technology and Research (A ⁎ STAR), Singapore for NUS-UIUC Joint Ph.D. Program.
- Coaxial electrohydrodynamic atomization
- Core-shell structured microspheres
- Mathematical modeling
- Multiphase flow
ASJC Scopus subject areas
- Chemistry (all)
- Chemical Engineering (all)
- Industrial and Manufacturing Engineering