Cocaine effects during d-amphetamine maintenance: A human laboratory analysis of safety, tolerability and efficacy

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Agonist replacement therapies are effective for managing substance abuse disorders including nicotine and opioid dependence. The results of preclinical laboratory studies and clinical trials indicate that agonist replacements like d-amphetamine may be a viable option for managing cocaine dependence. This experiment determined the physiological and behavioral effects of cocaine during d-amphetamine maintenance in seven cocaine-dependent participants. We predicted cocaine would be well tolerated during d-amphetamine maintenance. We also predicted d-amphetamine would attenuate the behavioral effects of cocaine. After 3-5 days of d-amphetamine maintenance (0, 15, and 30 mg/day), volunteers were administered ascending doses of cocaine (4, 30, 60 mg, IN) within a single session. Cocaine doses were separated by 90 min. Cocaine produced prototypical physiological (e.g., increased heart rate, blood pressure, and body temperature) and subject-rated (e.g., increased ratings of Good Effects) effects. During maintenance on the highest d-amphetamine dose, the heart rate increasing effects of cocaine were larger than observed during placebo maintenance. These effects were not clinically significant and no unexpected or serious adverse events were observed. d-Amphetamine attenuated some of the subject-rated effects of cocaine. These results are concordant with those of previous preclinical studies, human laboratory experiments and clinical trials, further suggesting that agonist replacement therapy may be a viable strategy for managing cocaine abuse. Additional research in humans is needed to determine whether d-amphetamine attenuates the effects of cocaine under different experimental conditions (e.g., higher cocaine doses) and behavioral arrangements (e.g., drug self-administration or discrimination).

Original languageEnglish
Pages (from-to)261-271
Number of pages11
JournalDrug and Alcohol Dependence
Issue number1-3
StatePublished - Jan 1 2009

Bibliographical note

Funding Information:
This research is supported by NIDA Grant R01 DA 021155 and NCRR Grant M01 RR02602. The NIDA and NCRR had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.


  • Agonist replacement therapy
  • Cocaine
  • Drug reinforcement
  • Humans
  • Pharmacotherapy
  • Physiological effects
  • Subjective effects
  • d-Amphetamine

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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