Cocaine improves inhibitory control in a human model of response conflict

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30 Scopus citations


The present study was designed to test the acute effects of cocaine on behavioral control in the presence and absence of motivational conflict. Adults (N = 14) with a history of stimulant use received oral cocaine hydrogen chloride (, 100, 200, and 300 mg) and performed a cue-dependent go/no-go task to measure inhibitory and activational mechanisms of behavioral control either with or without motivated conflict between the inhibition and the activation of responses. Cocaine improved response inhibition in both conflict conditions, as evident by a decrease in inhibitory failures following active doses. The current study provides a useful model to investigate the effects of other drugs reported to have performance-enhancing effects.

Original languageEnglish
Pages (from-to)327-335
Number of pages9
JournalExperimental and Clinical Psychopharmacology
Issue number4
StatePublished - Nov 2005


  • Behavioral control
  • Cocaine
  • Human
  • Inhibition

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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