Cognate interactions between helper T cells and B cells

R. J. Noelle; E. C. Snow

doi:10.1016/0167-5699(90)90142-v

Cognate interactions between helper T cells and B cells

R. J. Noelle, E. C. Snow

Microbiology, Immunology, and Molecular Genetics

Research output: Contribution to journal › Review article › peer-review

118 Scopus citations

Abstract

The mechanism by which mammals produce an antibody response after exposure to antigen has intrigued biologists for over a hundred years. Here, Randolph Noelle and Charles Snow review some of the experimental findings since the early 1970s that have advanced understanding of the mechanisms operating during B-cell activation by thymus-dependent (TD) antigens. They also propose a model for B-cell activation that emphasizes the critical role played by direct cellular interactions between B cells and helper T(T(H)) cells and seek to place into perspective the role played by the membrane immunoglobulin (mlg) receptor in cognate responses.

Original language	English
Pages (from-to)	361-368
Number of pages	8
Journal	Immunology Today
Volume	11
Issue number	10
DOIs	https://doi.org/10.1016/0167-5699(90)90142-v
State	Published - 1990

Bibliographical note

Funding Information:
We thank our colleagues William Bartlett. Li,a Marshall, Thomas Roszman, Karen Pollok and Mark L~eBenedette for helpful discussion and careful reading of the m~nuscript. This work was supported by grants NIH GM28468, GM37767 and AI26296 to RJN, and grant NIH AI23907 to ECS.

ASJC Scopus subject areas

Immunology

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10.1016/0167-5699(90)90142-v

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abstract = "The mechanism by which mammals produce an antibody response after exposure to antigen has intrigued biologists for over a hundred years. Here, Randolph Noelle and Charles Snow review some of the experimental findings since the early 1970s that have advanced understanding of the mechanisms operating during B-cell activation by thymus-dependent (TD) antigens. They also propose a model for B-cell activation that emphasizes the critical role played by direct cellular interactions between B cells and helper T(T(H)) cells and seek to place into perspective the role played by the membrane immunoglobulin (mlg) receptor in cognate responses.",

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AU - Snow, E. C.

N1 - Funding Information: We thank our colleagues William Bartlett. Li,a Marshall, Thomas Roszman, Karen Pollok and Mark L~eBenedette for helpful discussion and careful reading of the m~nuscript. This work was supported by grants NIH GM28468, GM37767 and AI26296 to RJN, and grant NIH AI23907 to ECS.

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Y1 - 1990

N2 - The mechanism by which mammals produce an antibody response after exposure to antigen has intrigued biologists for over a hundred years. Here, Randolph Noelle and Charles Snow review some of the experimental findings since the early 1970s that have advanced understanding of the mechanisms operating during B-cell activation by thymus-dependent (TD) antigens. They also propose a model for B-cell activation that emphasizes the critical role played by direct cellular interactions between B cells and helper T(T(H)) cells and seek to place into perspective the role played by the membrane immunoglobulin (mlg) receptor in cognate responses.

AB - The mechanism by which mammals produce an antibody response after exposure to antigen has intrigued biologists for over a hundred years. Here, Randolph Noelle and Charles Snow review some of the experimental findings since the early 1970s that have advanced understanding of the mechanisms operating during B-cell activation by thymus-dependent (TD) antigens. They also propose a model for B-cell activation that emphasizes the critical role played by direct cellular interactions between B cells and helper T(T(H)) cells and seek to place into perspective the role played by the membrane immunoglobulin (mlg) receptor in cognate responses.

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Cognate interactions between helper T cells and B cells

Abstract

Bibliographical note

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