Cognate interactions between helper T cells and B cells

R. J. Noelle; E. C. Snow

doi:10.1016/0167-5699(90)90142-v

Cognate interactions between helper T cells and B cells

R. J. Noelle, E. C. Snow

Microbiology, Immunology, and Molecular Genetics

Research output: Contribution to journal › Review article › peer-review

142 Scopus citations

Abstract

The mechanism by which mammals produce an antibody response after exposure to antigen has intrigued biologists for over a hundred years. Here, Randolph Noelle and Charles Snow review some of the experimental findings since the early 1970s that have advanced understanding of the mechanisms operating during B-cell activation by thymus-dependent (TD) antigens. They also propose a model for B-cell activation that emphasizes the critical role played by direct cellular interactions between B cells and helper T(T(H)) cells and seek to place into perspective the role played by the membrane immunoglobulin (mlg) receptor in cognate responses.

Original language	English
Pages (from-to)	361-368
Number of pages	8
Journal	Immunology Today
Volume	11
Issue number	10
DOIs	https://doi.org/10.1016/0167-5699(90)90142-v
State	Published - 1990

Bibliographical note

Funding Information:
We thank our colleagues William Bartlett. Li,a Marshall, Thomas Roszman, Karen Pollok and Mark L~eBenedette for helpful discussion and careful reading of the m~nuscript. This work was supported by grants NIH GM28468, GM37767 and AI26296 to RJN, and grant NIH AI23907 to ECS.

Funding

We thank our colleagues William Bartlett. Li,a Marshall, Thomas Roszman, Karen Pollok and Mark L~eBenedette for helpful discussion and careful reading of the m~nuscript. This work was supported by grants NIH GM28468, GM37767 and AI26296 to RJN, and grant NIH AI23907 to ECS.

Funders	Funder number
National Institutes of Health (NIH)	GM28468, GM37767, AI23907
National Institute of Allergy and Infectious Diseases	R01AI026296

ASJC Scopus subject areas

Immunology

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abstract = "The mechanism by which mammals produce an antibody response after exposure to antigen has intrigued biologists for over a hundred years. Here, Randolph Noelle and Charles Snow review some of the experimental findings since the early 1970s that have advanced understanding of the mechanisms operating during B-cell activation by thymus-dependent (TD) antigens. They also propose a model for B-cell activation that emphasizes the critical role played by direct cellular interactions between B cells and helper T(T(H)) cells and seek to place into perspective the role played by the membrane immunoglobulin (mlg) receptor in cognate responses.",

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AU - Noelle, R. J.

AU - Snow, E. C.

N1 - Funding Information: We thank our colleagues William Bartlett. Li,a Marshall, Thomas Roszman, Karen Pollok and Mark L~eBenedette for helpful discussion and careful reading of the m~nuscript. This work was supported by grants NIH GM28468, GM37767 and AI26296 to RJN, and grant NIH AI23907 to ECS.

PY - 1990

Y1 - 1990

N2 - The mechanism by which mammals produce an antibody response after exposure to antigen has intrigued biologists for over a hundred years. Here, Randolph Noelle and Charles Snow review some of the experimental findings since the early 1970s that have advanced understanding of the mechanisms operating during B-cell activation by thymus-dependent (TD) antigens. They also propose a model for B-cell activation that emphasizes the critical role played by direct cellular interactions between B cells and helper T(T(H)) cells and seek to place into perspective the role played by the membrane immunoglobulin (mlg) receptor in cognate responses.

AB - The mechanism by which mammals produce an antibody response after exposure to antigen has intrigued biologists for over a hundred years. Here, Randolph Noelle and Charles Snow review some of the experimental findings since the early 1970s that have advanced understanding of the mechanisms operating during B-cell activation by thymus-dependent (TD) antigens. They also propose a model for B-cell activation that emphasizes the critical role played by direct cellular interactions between B cells and helper T(T(H)) cells and seek to place into perspective the role played by the membrane immunoglobulin (mlg) receptor in cognate responses.

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AN - SCOPUS:0025050770

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JO - Immunology Today

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ER -

Cognate interactions between helper T cells and B cells

Abstract

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