Cognitive and motor function assessments in rodent models of traumatic brain injury

Danielle Scott; Kathryn E. Saatman

doi:10.1007/978-1-4939-8564-7_9

Cognitive and motor function assessments in rodent models of traumatic brain injury

Danielle Scott, Kathryn E. Saatman

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Cognitive and motor dysfunction is common in people who have experienced a traumatic brain injury (TBI). These deficits can include memory loss, learning impairment, dizziness, difficulty with balance, and loss of fine motor control and coordination. Cognitive function and vestibulomotor tasks have been widely used in clinically relevant rodent models of experimental TBI to study the relationship of neurobehavioral dysfunction to injury severity, secondary injury mechanisms, or putative therapeutic interventions. Here we describe paradigms for the novel object recognition task, a test of memory, and beam walking and rotarod tasks, tests of coordinated motor function. Key advantages and disadvantages are presented, and potential problems and adaptations of these behavioral tests are discussed.

Original language	English
Title of host publication	Neuromethods
Pages	139-154
Number of pages	16
DOIs	https://doi.org/10.1007/978-1-4939-8564-7_9
State	Published - 2018

Publication series

Name	Neuromethods
Volume	139
ISSN (Print)	0893-2336
ISSN (Electronic)	1940-6045

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media, LLC, part of Springer Nature 2018.

Funding

Supported, in part, by NIH R01 NS072302 and Kentucky Spinal Cord and Head Injury Research Trust grants 14-12A and 14-13A.

Funders	Funder number
National Institutes of Health (NIH)	R01 NS072302
Kentucky Spinal Cord and Head Injury Research Trust	14-12A, 14-13A

Keywords

Beam walking
Novel object recognition
Rotarod
Traumatic brain injury

ASJC Scopus subject areas

Psychiatry and Mental health
General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology
General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-1-4939-8564-7_9

Cite this

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Cognitive and motor function assessments in rodent models of traumatic brain injury

Abstract

Publication series

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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