Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins

Marcy J. Balunas, Manuel F. Grosso, Francisco A. Villa, Niclas Engene, Kerry L. McPhail, Kevin Tidgewell, Laura M. Pineda, Lena Gerwick, Carmenza Spadafora, Dennis E. Kyle, William H. Gerwick

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Four unsaturated polyketide lactone derivatives, coibacins A-D, were isolated from a Panamanian marine cyanobacterium, cf. Oscillatoria sp. The two different types of termini observed in these co-occurring metabolites, either a methyl cyclopropyl ring as seen in curacin A or a methyl vinyl chloride similar to that observed in the jamaicamides, suggest an intriguing flexibility in the "beta branch" forming biosynthetic process. The coibacins possess selective antileishmanial activity as well as potent anti-inflammatory activity.

Original languageEnglish
Pages (from-to)3878-3881
Number of pages4
JournalOrganic Letters
Volume14
Issue number15
DOIs
StatePublished - Aug 3 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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