Collateral damage in cancer chemotherapy: Oxidative stress in nontargeted tissues

Yumin Chen, Paiboon Jungsuwadee, Mary Vore, D. Allan Butterfield, Daret K. St. Clair

Research output: Contribution to journalReview articlepeer-review

296 Scopus citations

Abstract

Injury to nontargeted tissues in chemotherapy often complicates cancer treatment by limiting therapeutic dosages of anticancer drugs and by impairing the quality of life of patients during and after treatment. Oxidative stress, directly or indirectly caused by chemotherapeutics as exemplified by doxorubicin, is one of the underlying mechanisms of the toxicity of anticancer drugs in noncancerous tissues, including the heart and brain. A comprehensive understanding of the mechanisms of oxidative injury to normal tissue will be essential for the improvement of strategies to prevent or attenuate the toxicity of chemotherapeutic agents without compromising their chemotherapeutic value.

Original languageEnglish
Pages (from-to)147-156
Number of pages10
JournalMolecular Interventions
Volume7
Issue number3
DOIs
StatePublished - Jun 2007

ASJC Scopus subject areas

  • Molecular Medicine

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