TY - JOUR
T1 - Collateral damage in cancer chemotherapy
T2 - Oxidative stress in nontargeted tissues
AU - Chen, Yumin
AU - Jungsuwadee, Paiboon
AU - Vore, Mary
AU - Butterfield, D. Allan
AU - St. Clair, Daret K.
PY - 2007/6
Y1 - 2007/6
N2 - Injury to nontargeted tissues in chemotherapy often complicates cancer treatment by limiting therapeutic dosages of anticancer drugs and by impairing the quality of life of patients during and after treatment. Oxidative stress, directly or indirectly caused by chemotherapeutics as exemplified by doxorubicin, is one of the underlying mechanisms of the toxicity of anticancer drugs in noncancerous tissues, including the heart and brain. A comprehensive understanding of the mechanisms of oxidative injury to normal tissue will be essential for the improvement of strategies to prevent or attenuate the toxicity of chemotherapeutic agents without compromising their chemotherapeutic value.
AB - Injury to nontargeted tissues in chemotherapy often complicates cancer treatment by limiting therapeutic dosages of anticancer drugs and by impairing the quality of life of patients during and after treatment. Oxidative stress, directly or indirectly caused by chemotherapeutics as exemplified by doxorubicin, is one of the underlying mechanisms of the toxicity of anticancer drugs in noncancerous tissues, including the heart and brain. A comprehensive understanding of the mechanisms of oxidative injury to normal tissue will be essential for the improvement of strategies to prevent or attenuate the toxicity of chemotherapeutic agents without compromising their chemotherapeutic value.
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U2 - 10.1124/mi.7.3.6
DO - 10.1124/mi.7.3.6
M3 - Review article
C2 - 17609521
AN - SCOPUS:34347394526
SN - 1534-0384
VL - 7
SP - 147
EP - 156
JO - Molecular Interventions
JF - Molecular Interventions
IS - 3
ER -
