Collateral damage in cancer chemotherapy: Oxidative stress in nontargeted tissues

Yumin Chen; Paiboon Jungsuwadee; Mary Vore; D. Allan Butterfield; Daret K. St. Clair

doi:10.1124/mi.7.3.6

Collateral damage in cancer chemotherapy: Oxidative stress in nontargeted tissues

Yumin Chen
, Paiboon Jungsuwadee
, Mary Vore
, D. Allan Butterfield
, Daret K. St. Clair

Research output: Contribution to journal › Review article › peer-review

349 Scopus citations

Abstract

Injury to nontargeted tissues in chemotherapy often complicates cancer treatment by limiting therapeutic dosages of anticancer drugs and by impairing the quality of life of patients during and after treatment. Oxidative stress, directly or indirectly caused by chemotherapeutics as exemplified by doxorubicin, is one of the underlying mechanisms of the toxicity of anticancer drugs in noncancerous tissues, including the heart and brain. A comprehensive understanding of the mechanisms of oxidative injury to normal tissue will be essential for the improvement of strategies to prevent or attenuate the toxicity of chemotherapeutic agents without compromising their chemotherapeutic value.

Original language	English
Pages (from-to)	147-156
Number of pages	10
Journal	Molecular Interventions
Volume	7
Issue number	3
DOIs	https://doi.org/10.1124/mi.7.3.6
State	Published - Jun 2007

Funding

Funders	Funder number
National Childhood Cancer Registry – National Cancer Institute	R29CA049797
National Childhood Cancer Registry – National Cancer Institute

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Molecular Medicine

Access to Document

10.1124/mi.7.3.6

Cite this

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title = "Collateral damage in cancer chemotherapy: Oxidative stress in nontargeted tissues",

abstract = "Injury to nontargeted tissues in chemotherapy often complicates cancer treatment by limiting therapeutic dosages of anticancer drugs and by impairing the quality of life of patients during and after treatment. Oxidative stress, directly or indirectly caused by chemotherapeutics as exemplified by doxorubicin, is one of the underlying mechanisms of the toxicity of anticancer drugs in noncancerous tissues, including the heart and brain. A comprehensive understanding of the mechanisms of oxidative injury to normal tissue will be essential for the improvement of strategies to prevent or attenuate the toxicity of chemotherapeutic agents without compromising their chemotherapeutic value.",

author = "Yumin Chen and Paiboon Jungsuwadee and Mary Vore and Butterfield, \{D. Allan\} and \{St. Clair\}, \{Daret K.\}",

year = "2007",

month = jun,

doi = "10.1124/mi.7.3.6",

language = "English",

volume = "7",

pages = "147--156",

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TY - JOUR

T1 - Collateral damage in cancer chemotherapy

T2 - Oxidative stress in nontargeted tissues

AU - Chen, Yumin

AU - Jungsuwadee, Paiboon

AU - Vore, Mary

AU - Butterfield, D. Allan

AU - St. Clair, Daret K.

PY - 2007/6

Y1 - 2007/6

N2 - Injury to nontargeted tissues in chemotherapy often complicates cancer treatment by limiting therapeutic dosages of anticancer drugs and by impairing the quality of life of patients during and after treatment. Oxidative stress, directly or indirectly caused by chemotherapeutics as exemplified by doxorubicin, is one of the underlying mechanisms of the toxicity of anticancer drugs in noncancerous tissues, including the heart and brain. A comprehensive understanding of the mechanisms of oxidative injury to normal tissue will be essential for the improvement of strategies to prevent or attenuate the toxicity of chemotherapeutic agents without compromising their chemotherapeutic value.

AB - Injury to nontargeted tissues in chemotherapy often complicates cancer treatment by limiting therapeutic dosages of anticancer drugs and by impairing the quality of life of patients during and after treatment. Oxidative stress, directly or indirectly caused by chemotherapeutics as exemplified by doxorubicin, is one of the underlying mechanisms of the toxicity of anticancer drugs in noncancerous tissues, including the heart and brain. A comprehensive understanding of the mechanisms of oxidative injury to normal tissue will be essential for the improvement of strategies to prevent or attenuate the toxicity of chemotherapeutic agents without compromising their chemotherapeutic value.

UR - https://www.scopus.com/pages/publications/34347394526

UR - https://www.scopus.com/pages/publications/34347394526#tab=citedBy

U2 - 10.1124/mi.7.3.6

DO - 10.1124/mi.7.3.6

M3 - Review article

C2 - 17609521

AN - SCOPUS:34347394526

SN - 1534-0384

VL - 7

SP - 147

EP - 156

JO - Molecular Interventions

JF - Molecular Interventions

IS - 3

ER -

Collateral damage in cancer chemotherapy: Oxidative stress in nontargeted tissues

Abstract

Funding

UN SDGs

ASJC Scopus subject areas

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