Combinatorial Biosynthesis–An Approach in the Near Future?

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48 Scopus citations


A gene library has been conceived for the construction of multienzyme complexes from natural and altered building blocks. The first encouraging results have been achieved with polyketide synthases (PKSs): enzyme hybrids were formed by “mixing” genes coding for PKSs, which provide novel polyketides such as 1. The ring frameworks, configurations, and/or functional groups of these novel compounds depend on the manipulated genes. (Figure Presented.)

Original languageEnglish
Pages (from-to)881-885
Number of pages5
JournalAngewandte Chemie International Edition in English
Issue number8
StatePublished - May 2 1995


  • biosyntheses
  • gene technology
  • polyketides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry (all)


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