Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

María Pérez, Felipe Lombó, Lili Zhu, Miranda Gibson, Alfredo F. Braña, Jürgen Rohr, José A. Salas, Carmen Méndez

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

L- and D-stereoisomers of amicetose were generated by combining sugar biosynthesis genes from four different antibiotic gene clusters and both sugars were transferred to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase.

Original languageEnglish
Pages (from-to)1604-1606
Number of pages3
JournalChemical Communications
Issue number12
DOIs
StatePublished - Mar 28 2005

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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