Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

María Pérez; Felipe Lombó; Lili Zhu; Miranda Gibson; Alfredo F. Braña; Jürgen Rohr; José A. Salas; Carmen Méndez

doi:10.1039/b417815g

Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

María Pérez, Felipe Lombó, Lili Zhu, Miranda Gibson, Alfredo F. Braña, Jürgen Rohr, José A. Salas, Carmen Méndez

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

L- and D-stereoisomers of amicetose were generated by combining sugar biosynthesis genes from four different antibiotic gene clusters and both sugars were transferred to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase.

Original language	English
Pages (from-to)	1604-1606
Number of pages	3
Journal	Chemical Communications
Issue number	12
DOIs	https://doi.org/10.1039/b417815g
State	Published - Mar 28 2005

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry (all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins",

abstract = "L- and D-stereoisomers of amicetose were generated by combining sugar biosynthesis genes from four different antibiotic gene clusters and both sugars were transferred to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase.",

author = "Mar{\'i}a P{\'e}rez and Felipe Lomb{\'o} and Lili Zhu and Miranda Gibson and Bra{\~n}a, {Alfredo F.} and J{\"u}rgen Rohr and Salas, {Jos{\'e} A.} and Carmen M{\'e}ndez",

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T1 - Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

AU - Pérez, María

AU - Lombó, Felipe

AU - Zhu, Lili

AU - Gibson, Miranda

AU - Braña, Alfredo F.

AU - Rohr, Jürgen

AU - Salas, José A.

AU - Méndez, Carmen

PY - 2005/3/28

Y1 - 2005/3/28

N2 - L- and D-stereoisomers of amicetose were generated by combining sugar biosynthesis genes from four different antibiotic gene clusters and both sugars were transferred to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase.

AB - L- and D-stereoisomers of amicetose were generated by combining sugar biosynthesis genes from four different antibiotic gene clusters and both sugars were transferred to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase.

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Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

Abstract

ASJC Scopus subject areas

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