Common pitfalls and diagnostic challenges in the application of LI-RADS CT/MRI algorithms: a comprehensive review

The Liver Imaging Reporting and Data System (LI-RADS) was developed to standardize the interpretation and reporting of liver observations in at-risk populations, aiding in the diagnosis of hepatocellular carcinoma (HCC). Despite its advantages, the application of LI-RADS can be challenging due to the complexity of liver pathology and imaging interpretation. This comprehensive review highlights common pitfalls encountered in LI-RADS application and offers practical strategies to enhance diagnostic accuracy and consistency among radiologists. Key areas of difficulty include misapplication in non-high-risk populations, misinterpretation of major imaging features such as arterial phase hyperenhancement and washout, and incorrect application of ancillary features. Additionally, the review addresses challenges related to atypical HCC presentations and HCC mimics. By recognizing and addressing these pitfalls, radiologists can improve diagnostic accuracy and avoid common mistakes in the diagnosis of HCC.