A diet consisting of a high intake of saturated fat and refined sugars is characteristic of a Western-diet and has been shown to have a substantial negative effect on human health. Expression proteomics were used to investigate changes to the parietal lobe proteome of rhesus monkeys consuming either a high fat and sugar (HFS) diet, a HFS diet supplemented with resveratrol (HFS+RSV), or a healthy control diet for 2 years. Here we discuss the modifications in the levels of 12 specific proteins involved in various cellular systems including metabolism, neurotransmission, structural integrity, and general cellular signaling following a nutritional intervention. Our results contribute to a better understanding of the mechanisms by which resveratrol functions through the up- or down-regulation of proteins in different cellular sub-systems to affect the overall health of the brain.
|Number of pages||11|
|Journal||Journal of Nutritional Biochemistry|
|State||Published - Jan 1 2017|
Bibliographical noteFunding Information:
This study was funded in part by the Intramural Research program of the National Institute on Aging, NIH. We thank the National Institute on Aging for providing the brain samples used in this study.
© 2016 Elsevier Inc.
- Rhesus monkey
- Western diet
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Molecular Biology
- Nutrition and Dietetics
- Clinical Biochemistry