Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function

Aaron M. Swomley; Judy C. Triplett; Jeriel T. Keeney; Govind Warrier; Kevin J. Pearson; Julie A. Mattison; Rafael de Cabo; Jian Cai; Jon B. Klein; D. Allan Butterfield

doi:10.1016/j.jnutbio.2016.10.006

Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function

Aaron M. Swomley, Judy C. Triplett, Jeriel T. Keeney, Govind Warrier, Kevin J. Pearson, Julie A. Mattison, Rafael de Cabo, Jian Cai, Jon B. Klein, D. Allan Butterfield

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A diet consisting of a high intake of saturated fat and refined sugars is characteristic of a Western-diet and has been shown to have a substantial negative effect on human health. Expression proteomics were used to investigate changes to the parietal lobe proteome of rhesus monkeys consuming either a high fat and sugar (HFS) diet, a HFS diet supplemented with resveratrol (HFS+RSV), or a healthy control diet for 2 years. Here we discuss the modifications in the levels of 12 specific proteins involved in various cellular systems including metabolism, neurotransmission, structural integrity, and general cellular signaling following a nutritional intervention. Our results contribute to a better understanding of the mechanisms by which resveratrol functions through the up- or down-regulation of proteins in different cellular sub-systems to affect the overall health of the brain.

Original language	English
Pages (from-to)	169-179
Number of pages	11
Journal	Journal of Nutritional Biochemistry
Volume	39
DOIs	https://doi.org/10.1016/j.jnutbio.2016.10.006
State	Published - Jan 1 2017

Bibliographical note

Funding Information:
This study was funded in part by the Intramural Research program of the National Institute on Aging, NIH. We thank the National Institute on Aging for providing the brain samples used in this study.

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

Brain
Proteomics
Resveratrol
Rhesus monkey
Western diet

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Biology
Nutrition and Dietetics
Clinical Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jnutbio.2016.10.006

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Swomley, A. M., Triplett, J. C., Keeney, J. T., Warrier, G., Pearson, K. J., Mattison, J. A., de Cabo, R., Cai, J., Klein, J. B., & Butterfield, D. A. (2017). Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function. Journal of Nutritional Biochemistry, 39, 169-179. https://doi.org/10.1016/j.jnutbio.2016.10.006

Swomley, Aaron M. ; Triplett, Judy C. ; Keeney, Jeriel T. et al. / Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet : Insights into the roles of unhealthy diets and resveratrol on function. In: Journal of Nutritional Biochemistry. 2017 ; Vol. 39. pp. 169-179.

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title = "Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function",

abstract = "A diet consisting of a high intake of saturated fat and refined sugars is characteristic of a Western-diet and has been shown to have a substantial negative effect on human health. Expression proteomics were used to investigate changes to the parietal lobe proteome of rhesus monkeys consuming either a high fat and sugar (HFS) diet, a HFS diet supplemented with resveratrol (HFS+RSV), or a healthy control diet for 2 years. Here we discuss the modifications in the levels of 12 specific proteins involved in various cellular systems including metabolism, neurotransmission, structural integrity, and general cellular signaling following a nutritional intervention. Our results contribute to a better understanding of the mechanisms by which resveratrol functions through the up- or down-regulation of proteins in different cellular sub-systems to affect the overall health of the brain.",

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author = "Swomley, {Aaron M.} and Triplett, {Judy C.} and Keeney, {Jeriel T.} and Govind Warrier and Pearson, {Kevin J.} and Mattison, {Julie A.} and {de Cabo}, Rafael and Jian Cai and Klein, {Jon B.} and Butterfield, {D. Allan}",

note = "Funding Information: This study was funded in part by the Intramural Research program of the National Institute on Aging, NIH. We thank the National Institute on Aging for providing the brain samples used in this study. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

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Swomley, AM, Triplett, JC, Keeney, JT, Warrier, G, Pearson, KJ, Mattison, JA, de Cabo, R, Cai, J, Klein, JB & Butterfield, DA 2017, 'Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function', Journal of Nutritional Biochemistry, vol. 39, pp. 169-179. https://doi.org/10.1016/j.jnutbio.2016.10.006

Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function. / Swomley, Aaron M.; Triplett, Judy C.; Keeney, Jeriel T. et al.
In: Journal of Nutritional Biochemistry, Vol. 39, 01.01.2017, p. 169-179.

Research output: Contribution to journal › Article › peer-review

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AU - Swomley, Aaron M.

AU - Triplett, Judy C.

AU - Keeney, Jeriel T.

AU - Warrier, Govind

AU - Pearson, Kevin J.

AU - Mattison, Julie A.

AU - de Cabo, Rafael

AU - Cai, Jian

AU - Klein, Jon B.

AU - Butterfield, D. Allan

N1 - Funding Information: This study was funded in part by the Intramural Research program of the National Institute on Aging, NIH. We thank the National Institute on Aging for providing the brain samples used in this study. Publisher Copyright: © 2016 Elsevier Inc.

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Y1 - 2017/1/1

N2 - A diet consisting of a high intake of saturated fat and refined sugars is characteristic of a Western-diet and has been shown to have a substantial negative effect on human health. Expression proteomics were used to investigate changes to the parietal lobe proteome of rhesus monkeys consuming either a high fat and sugar (HFS) diet, a HFS diet supplemented with resveratrol (HFS+RSV), or a healthy control diet for 2 years. Here we discuss the modifications in the levels of 12 specific proteins involved in various cellular systems including metabolism, neurotransmission, structural integrity, and general cellular signaling following a nutritional intervention. Our results contribute to a better understanding of the mechanisms by which resveratrol functions through the up- or down-regulation of proteins in different cellular sub-systems to affect the overall health of the brain.

AB - A diet consisting of a high intake of saturated fat and refined sugars is characteristic of a Western-diet and has been shown to have a substantial negative effect on human health. Expression proteomics were used to investigate changes to the parietal lobe proteome of rhesus monkeys consuming either a high fat and sugar (HFS) diet, a HFS diet supplemented with resveratrol (HFS+RSV), or a healthy control diet for 2 years. Here we discuss the modifications in the levels of 12 specific proteins involved in various cellular systems including metabolism, neurotransmission, structural integrity, and general cellular signaling following a nutritional intervention. Our results contribute to a better understanding of the mechanisms by which resveratrol functions through the up- or down-regulation of proteins in different cellular sub-systems to affect the overall health of the brain.

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Swomley AM, Triplett JC, Keeney JT, Warrier G, Pearson KJ, Mattison JA et al. Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function. Journal of Nutritional Biochemistry. 2017 Jan 1;39:169-179. doi: 10.1016/j.jnutbio.2016.10.006

Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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