TY - JOUR
T1 - Comparison of a rapid hepatitis B immunization schedule to the standard schedule for adults
AU - Marsano, Luis S.
AU - Greenberg, Richard N.
AU - Kirkpatrick, Robert B.
AU - Zetterman, Rowen K.
AU - Christiansen, Abigail
AU - Smith, Daniel J.
AU - DeMedina, Maria D.
AU - Schiff, Eugene R.
PY - 1996/1
Y1 - 1996/1
N2 - We report a prospective, randomized, single-blinded trial comparing immunogenicity of rapid (0, 1, and 2 months) versus standard schedule (0, 1, 6 months) hepatitis B vaccinations of healthy adults with recombinant hepatitis B vaccine (Engerix-B, 20 μg i.m.) Volunteers (230 of 234) negative to hepatitis B were randomized and completed the study. Groups were similar in age, weight, race, and obesity rate, but the rapid schedule group had more women. Both groups reached ≥100 mIU/mL at a similar rate, but a higher seroprotection rate at ≥500 mIU/mL was reached by the standard schedule. No demographic variables influenced the effect of dose schedule on anti- hepatitis B titer. We conclude that rapid schedule vaccination gives a rate that is quicker than, and identical to, the rate of seroprotection of the standard schedule vaccination.
AB - We report a prospective, randomized, single-blinded trial comparing immunogenicity of rapid (0, 1, and 2 months) versus standard schedule (0, 1, 6 months) hepatitis B vaccinations of healthy adults with recombinant hepatitis B vaccine (Engerix-B, 20 μg i.m.) Volunteers (230 of 234) negative to hepatitis B were randomized and completed the study. Groups were similar in age, weight, race, and obesity rate, but the rapid schedule group had more women. Both groups reached ≥100 mIU/mL at a similar rate, but a higher seroprotection rate at ≥500 mIU/mL was reached by the standard schedule. No demographic variables influenced the effect of dose schedule on anti- hepatitis B titer. We conclude that rapid schedule vaccination gives a rate that is quicker than, and identical to, the rate of seroprotection of the standard schedule vaccination.
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M3 - Article
C2 - 8561109
AN - SCOPUS:0030049232
SN - 0002-9270
VL - 91
SP - 111
EP - 115
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 1
ER -