Comparison of acute behavioral effects of sustained-release and immediate-release methylphenidate

Scott H. Kollins, Craig R. Rush, Peggy J. Pazzaglia, Jeffery A. Ali

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

The rate of onset of a drug's effect is an important determinant of its abuse potential. This experiment examined the acute behavioral effects of orally administered sustained-release methylphenidate (SR; 20-40 mg), immediate-release methylphenidate (IR; 20-40 mg), and placebo in 10 healthy volunteers. Drag effects were assessed before drug administration and periodically afterwards for 6 hr using drug-effect questionnaires and performance measures that are sensitive to the acute effects of stimulants. The IR formulation produced stimulant-like drug effects (e.g., increased ratings of 'good effects') that generally varied as a function of dose and time. The SR formulation produced only transient effects on these measures. These findings are consistent with previous research on the influence of rate of onset using other drugs and suggest that the abuse potential of IR methylphenidate may be greater than that of SR methylphenidate.

Original languageEnglish
Pages (from-to)367-374
Number of pages8
JournalExperimental and Clinical Psychopharmacology
Volume6
Issue number4
DOIs
StatePublished - Nov 1998

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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