Comparison of laser microprobe mass spectrometry (LMMS) and micro particle induced X-ray emission (micro-PIXE) for the analysis of senile plaques in Alzheimer's disease: A preliminary study

M. A. Lovell; J. D. Robertson; W. D. Ehmann; W. R. Markesbery; W. J. Teesdale; J. L. Campbell

doi:10.1007/BF02036467

Comparison of laser microprobe mass spectrometry (LMMS) and micro particle induced X-ray emission (micro-PIXE) for the analysis of senile plaques in Alzheimer's disease: A preliminary study

M. A. Lovell, J. D. Robertson, W. D. Ehmann, W. R. Markesbery, W. J. Teesdale, J. L. Campbell

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Results of micro-PIXE analysis of senile plaques (SP) in Alzheimer's disease (AD) brain have been utilized to independently confirm levels of iron (Fe) as measured by LMMS in adjacent brain sections. LMMS concentrations were calculated based on the preparation and analysis of an iron calibration curve prepared in our laboratory. The LMMS standards consist of iron cis-dicyclohexano-18-crown-6 ether coordination complexes dissolved in Spurr's low viscosity embedding medium. To our knowledge, this is the first report of the use of micro-PIXE, with its spatial resolution and detection limits comparable to that of LMMS, in the validation of LMMS results. The agreement observed between results obtained for Fe by micro-PIXE and LMMS indicates that the use of our LMMS standards, at least in the case of Fe, yields accurate results.

Original language	English
Pages (from-to)	7-12
Number of pages	6
Journal	Journal of Radioanalytical and Nuclear Chemistry Articles
Volume	195
Issue number	1
DOIs	https://doi.org/10.1007/BF02036467
State	Published - Aug 1995

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02036467

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Lovell, M. A., Robertson, J. D., Ehmann, W. D., Markesbery, W. R., Teesdale, W. J., & Campbell, J. L. (1995). Comparison of laser microprobe mass spectrometry (LMMS) and micro particle induced X-ray emission (micro-PIXE) for the analysis of senile plaques in Alzheimer's disease: A preliminary study. Journal of Radioanalytical and Nuclear Chemistry Articles, 195(1), 7-12. https://doi.org/10.1007/BF02036467

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abstract = "Results of micro-PIXE analysis of senile plaques (SP) in Alzheimer's disease (AD) brain have been utilized to independently confirm levels of iron (Fe) as measured by LMMS in adjacent brain sections. LMMS concentrations were calculated based on the preparation and analysis of an iron calibration curve prepared in our laboratory. The LMMS standards consist of iron cis-dicyclohexano-18-crown-6 ether coordination complexes dissolved in Spurr's low viscosity embedding medium. To our knowledge, this is the first report of the use of micro-PIXE, with its spatial resolution and detection limits comparable to that of LMMS, in the validation of LMMS results. The agreement observed between results obtained for Fe by micro-PIXE and LMMS indicates that the use of our LMMS standards, at least in the case of Fe, yields accurate results.",

author = "Lovell, {M. A.} and Robertson, {J. D.} and Ehmann, {W. D.} and Markesbery, {W. R.} and Teesdale, {W. J.} and Campbell, {J. L.}",

year = "1995",

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doi = "10.1007/BF02036467",

language = "English",

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pages = "7--12",

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Lovell, MA, Robertson, JD, Ehmann, WD, Markesbery, WR, Teesdale, WJ & Campbell, JL 1995, 'Comparison of laser microprobe mass spectrometry (LMMS) and micro particle induced X-ray emission (micro-PIXE) for the analysis of senile plaques in Alzheimer's disease: A preliminary study', Journal of Radioanalytical and Nuclear Chemistry Articles, vol. 195, no. 1, pp. 7-12. https://doi.org/10.1007/BF02036467

Comparison of laser microprobe mass spectrometry (LMMS) and micro particle induced X-ray emission (micro-PIXE) for the analysis of senile plaques in Alzheimer's disease: A preliminary study. / Lovell, M. A.; Robertson, J. D.; Ehmann, W. D. et al.
In: Journal of Radioanalytical and Nuclear Chemistry Articles, Vol. 195, No. 1, 08.1995, p. 7-12.

Research output: Contribution to journal › Article › peer-review

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AU - Lovell, M. A.

AU - Robertson, J. D.

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AU - Teesdale, W. J.

AU - Campbell, J. L.

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AB - Results of micro-PIXE analysis of senile plaques (SP) in Alzheimer's disease (AD) brain have been utilized to independently confirm levels of iron (Fe) as measured by LMMS in adjacent brain sections. LMMS concentrations were calculated based on the preparation and analysis of an iron calibration curve prepared in our laboratory. The LMMS standards consist of iron cis-dicyclohexano-18-crown-6 ether coordination complexes dissolved in Spurr's low viscosity embedding medium. To our knowledge, this is the first report of the use of micro-PIXE, with its spatial resolution and detection limits comparable to that of LMMS, in the validation of LMMS results. The agreement observed between results obtained for Fe by micro-PIXE and LMMS indicates that the use of our LMMS standards, at least in the case of Fe, yields accurate results.

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Lovell MA, Robertson JD, Ehmann WD, Markesbery WR, Teesdale WJ, Campbell JL. Comparison of laser microprobe mass spectrometry (LMMS) and micro particle induced X-ray emission (micro-PIXE) for the analysis of senile plaques in Alzheimer's disease: A preliminary study. Journal of Radioanalytical and Nuclear Chemistry Articles. 1995 Aug;195(1):7-12. doi: 10.1007/BF02036467

Comparison of laser microprobe mass spectrometry (LMMS) and micro particle induced X-ray emission (micro-PIXE) for the analysis of senile plaques in Alzheimer's disease: A preliminary study

Abstract

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UN SDGs

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