Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Sinjini Sikdar, Roby Joehanes, Bonnie R. Joubert, Cheng Jian Xu, Marta Vives-Usano, Faisal I. Rezwan, Janine F. Felix, James M. Ward, Weihua Guan, Rebecca C. Richmond, Jennifer A. Brody, Leanne K. Küpers, Nour Baïz, Siri E. Håberg, Jennifer A. Smith, Sarah E. Reese, Stella Aslibekyan, Cathrine Hoyo, Radhika Dhingra, Christina A. MarkunasTao Xu, Lindsay M. Reynolds, Allan C. Just, Pooja R. Mandaviya, Akram Ghantous, Brian D. Bennett, Tianyuan Wang, The Bios Consortium, Kelly M. Bakulski, Erik Melen, Shanshan Zhao, Jianping Jin, Zdenko Herceg, Joyce Van Meurs, Jack A. Taylor, Andrea A. Baccarelli, Susan K. Murphy, Yongmei Liu, Monica Cheng Munthe-Kaas, Ian J. Deary, Wenche Nystad, Melanie Waldenberger, Isabella Annesi-Maesano, Karen Conneely, Vincent W.V. Jaddoe, Donna Arnett, Harold Snieder, Sharon L.R. Kardia, Caroline L. Relton, Ken K. Ong, Susan Ewart, Hortensia Moreno-Macias, Isabelle Romieu, Nona Sotoodehnia, Myriam Fornage, Alison Motsinger-Reif, Gerard H. Koppelman, Mariona Bustamante, Daniel Levy, Stephanie J. London

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

Original languageEnglish
Pages (from-to)1487-1500
Number of pages14
Issue number13
StatePublished - Oct 2019

Bibliographical note

Publisher Copyright:
© 2019 Sinjini Sikdar.


  • cigarette smoking
  • epigenetics
  • infant
  • maternal exposure
  • methylation

ASJC Scopus subject areas

  • Genetics
  • Cancer Research


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