Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Sinjini Sikdar; Roby Joehanes; Bonnie R. Joubert; Cheng Jian Xu; Marta Vives-Usano; Faisal I. Rezwan; Janine F. Felix; James M. Ward; Weihua Guan; Rebecca C. Richmond; Jennifer A. Brody; Leanne K. Küpers; Nour Baïz; Siri E. Håberg; Jennifer A. Smith; Sarah E. Reese; Stella Aslibekyan; Cathrine Hoyo; Radhika Dhingra; Christina A. Markunas; Tao Xu; Lindsay M. Reynolds; Allan C. Just; Pooja R. Mandaviya; Akram Ghantous; Brian D. Bennett; Tianyuan Wang; The Bios Consortium; Kelly M. Bakulski; Erik Melen; Shanshan Zhao; Jianping Jin; Zdenko Herceg; Joyce Van Meurs; Jack A. Taylor; Andrea A. Baccarelli; Susan K. Murphy; Yongmei Liu; Monica Cheng Munthe-Kaas; Ian J. Deary; Wenche Nystad; Melanie Waldenberger; Isabella Annesi-Maesano; Karen Conneely; Vincent W.V. Jaddoe; Donna Arnett; Harold Snieder; Sharon L.R. Kardia; Caroline L. Relton; Ken K. Ong; Susan Ewart; Hortensia Moreno-Macias; Isabelle Romieu; Nona Sotoodehnia; Myriam Fornage; Alison Motsinger-Reif; Gerard H. Koppelman; Mariona Bustamante; Daniel Levy; Stephanie J. London

doi:10.2217/epi-2019-0066

Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Sinjini Sikdar, Roby Joehanes, Bonnie R. Joubert, Cheng Jian Xu, Marta Vives-Usano, Faisal I. Rezwan, Janine F. Felix, James M. Ward, Weihua Guan, Rebecca C. Richmond, Jennifer A. Brody, Leanne K. Küpers, Nour Baïz, Siri E. Håberg, Jennifer A. Smith, Sarah E. Reese, Stella Aslibekyan, Cathrine Hoyo, Radhika Dhingra, Christina A. MarkunasTao Xu, Lindsay M. Reynolds, Allan C. Just, Pooja R. Mandaviya, Akram Ghantous, Brian D. Bennett, Tianyuan Wang, The Bios Consortium, Kelly M. Bakulski, Erik Melen, Shanshan Zhao, Jianping Jin, Zdenko Herceg, Joyce Van Meurs, Jack A. Taylor, Andrea A. Baccarelli, Susan K. Murphy, Yongmei Liu, Monica Cheng Munthe-Kaas, Ian J. Deary, Wenche Nystad, Melanie Waldenberger, Isabella Annesi-Maesano, Karen Conneely, Vincent W.V. Jaddoe, Donna Arnett, Harold Snieder, Sharon L.R. Kardia, Caroline L. Relton, Ken K. Ong, Susan Ewart, Hortensia Moreno-Macias, Isabelle Romieu, Nona Sotoodehnia, Myriam Fornage, Alison Motsinger-Reif, Gerard H. Koppelman, Mariona Bustamante, Daniel Levy, Stephanie J. London

College of Public Health

Research output: Contribution to journal › Article › peer-review

29 Citations (SciVal)

Abstract

Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

Original language	English
Pages (from-to)	1487-1500
Number of pages	14
Journal	Epigenomics
Volume	11
Issue number	13
DOIs	https://doi.org/10.2217/epi-2019-0066
State	Published - Oct 2019

Bibliographical note

Funding Information:
29Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA 30Department of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA 31Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands 32Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands 33Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France 34Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 35Westat, Durham, NC 27703, USA 36Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York City, NY 10032, USA 37Departments of Obstetrics & Gynecology & Pathology, Duke University School of Medicine, Durham, NC 27708, USA 38Department of Pediatrics, Oslo University Hospital, Oslo, Norway 39National Institute of Public Health, Oslo, Norway 40Centre for Cognitive Ageing & Cognitive Epidemiology, Edinburgh, UK 41Department of Psychology, University of Edinburgh, Edinburgh, UK 42Division of Mental & Physical Health, Norwegian Institute of Public Health, Oslo, Norway 43Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany 44Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA 45MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK 46Department of Paediatrics, University of Cambridge, Cambridge, UK 47Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824, USA 48Autonomous Metropolitan University Iztapalapa, Mexico City, Mexico 49Nutrition & Metabolism Section, International Agency for Research on Cancer, Lyon, France 50Center for Research on Population Health, National Institute of Public Health, Mexico 51Hubert Department of Global Health, Emory University, Atlanta, GA 30329, USA 52Institute of Molecular Medicine & Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225, USA 53Population Sciences Branch, National Heart, Lung, & Blood Institute, National Institutes of Health, Bethesda, MD 01702, USA *Author for correspondence: london2@niehs.nih.gov

Funding Information:
Funded by the Intramural Research Program of National Institutes of Health (National Institute of Environmental Health Sciences ZO1 ES49019) in addition to funding for individual authors and cohorts listed in the Supplementary Acknowledgements and Funding document. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

Publisher Copyright:
© 2019 Sinjini Sikdar.

Keywords

cigarette smoking
epigenetics
infant
maternal exposure
methylation

ASJC Scopus subject areas

Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2217/epi-2019-0066

Cite this

Sikdar, S., Joehanes, R., Joubert, B. R., Xu, C. J., Vives-Usano, M., Rezwan, F. I., Felix, J. F., Ward, J. M., Guan, W., Richmond, R. C., Brody, J. A., Küpers, L. K., Baïz, N., Håberg, S. E., Smith, J. A., Reese, S. E., Aslibekyan, S., Hoyo, C., Dhingra, R., ... London, S. J. (2019). Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics, 11(13), 1487-1500. https://doi.org/10.2217/epi-2019-0066

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title = "Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking",

abstract = "Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.",

keywords = "cigarette smoking, epigenetics, infant, maternal exposure, methylation",

author = "Sinjini Sikdar and Roby Joehanes and Joubert, {Bonnie R.} and Xu, {Cheng Jian} and Marta Vives-Usano and Rezwan, {Faisal I.} and Felix, {Janine F.} and Ward, {James M.} and Weihua Guan and Richmond, {Rebecca C.} and Brody, {Jennifer A.} and K{\"u}pers, {Leanne K.} and Nour Ba{\"i}z and H{\aa}berg, {Siri E.} and Smith, {Jennifer A.} and Reese, {Sarah E.} and Stella Aslibekyan and Cathrine Hoyo and Radhika Dhingra and Markunas, {Christina A.} and Tao Xu and Reynolds, {Lindsay M.} and Just, {Allan C.} and Mandaviya, {Pooja R.} and Akram Ghantous and Bennett, {Brian D.} and Tianyuan Wang and Consortium, {The Bios} and Bakulski, {Kelly M.} and Erik Melen and Shanshan Zhao and Jianping Jin and Zdenko Herceg and {Van Meurs}, Joyce and Taylor, {Jack A.} and Baccarelli, {Andrea A.} and Murphy, {Susan K.} and Yongmei Liu and Munthe-Kaas, {Monica Cheng} and Deary, {Ian J.} and Wenche Nystad and Melanie Waldenberger and Isabella Annesi-Maesano and Karen Conneely and Jaddoe, {Vincent W.V.} and Donna Arnett and Harold Snieder and Kardia, {Sharon L.R.} and Relton, {Caroline L.} and Ong, {Ken K.} and Susan Ewart and Hortensia Moreno-Macias and Isabelle Romieu and Nona Sotoodehnia and Myriam Fornage and Alison Motsinger-Reif and Koppelman, {Gerard H.} and Mariona Bustamante and Daniel Levy and London, {Stephanie J.}",

note = "Funding Information: 29Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA 30Department of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA 31Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands 32Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands 33Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France 34Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 35Westat, Durham, NC 27703, USA 36Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York City, NY 10032, USA 37Departments of Obstetrics & Gynecology & Pathology, Duke University School of Medicine, Durham, NC 27708, USA 38Department of Pediatrics, Oslo University Hospital, Oslo, Norway 39National Institute of Public Health, Oslo, Norway 40Centre for Cognitive Ageing & Cognitive Epidemiology, Edinburgh, UK 41Department of Psychology, University of Edinburgh, Edinburgh, UK 42Division of Mental & Physical Health, Norwegian Institute of Public Health, Oslo, Norway 43Institute of Epidemiology, Helmholtz Zentrum M{\"u}nchen, German Research Center for Environmental Health, Neuherberg, Germany 44Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA 45MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK 46Department of Paediatrics, University of Cambridge, Cambridge, UK 47Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824, USA 48Autonomous Metropolitan University Iztapalapa, Mexico City, Mexico 49Nutrition & Metabolism Section, International Agency for Research on Cancer, Lyon, France 50Center for Research on Population Health, National Institute of Public Health, Mexico 51Hubert Department of Global Health, Emory University, Atlanta, GA 30329, USA 52Institute of Molecular Medicine & Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225, USA 53Population Sciences Branch, National Heart, Lung, & Blood Institute, National Institutes of Health, Bethesda, MD 01702, USA *Author for correspondence: london2@niehs.nih.gov Funding Information: Funded by the Intramural Research Program of National Institutes of Health (National Institute of Environmental Health Sciences ZO1 ES49019) in addition to funding for individual authors and cohorts listed in the Supplementary Acknowledgements and Funding document. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2019 Sinjini Sikdar.",

year = "2019",

month = oct,

doi = "10.2217/epi-2019-0066",

language = "English",

volume = "11",

pages = "1487--1500",

number = "13",

}

Sikdar, S, Joehanes, R, Joubert, BR, Xu, CJ, Vives-Usano, M, Rezwan, FI, Felix, JF, Ward, JM, Guan, W, Richmond, RC, Brody, JA, Küpers, LK, Baïz, N, Håberg, SE, Smith, JA, Reese, SE, Aslibekyan, S, Hoyo, C, Dhingra, R, Markunas, CA, Xu, T, Reynolds, LM, Just, AC, Mandaviya, PR, Ghantous, A, Bennett, BD, Wang, T, Consortium, TB, Bakulski, KM, Melen, E, Zhao, S, Jin, J, Herceg, Z, Van Meurs, J, Taylor, JA, Baccarelli, AA, Murphy, SK, Liu, Y, Munthe-Kaas, MC, Deary, IJ, Nystad, W, Waldenberger, M, Annesi-Maesano, I, Conneely, K, Jaddoe, VWV, Arnett, D, Snieder, H, Kardia, SLR, Relton, CL, Ong, KK, Ewart, S, Moreno-Macias, H, Romieu, I, Sotoodehnia, N, Fornage, M, Motsinger-Reif, A, Koppelman, GH, Bustamante, M, Levy, D & London, SJ 2019, 'Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking', Epigenomics, vol. 11, no. 13, pp. 1487-1500. https://doi.org/10.2217/epi-2019-0066

TY - JOUR

T1 - Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

AU - Sikdar, Sinjini

AU - Joehanes, Roby

AU - Joubert, Bonnie R.

AU - Xu, Cheng Jian

AU - Vives-Usano, Marta

AU - Rezwan, Faisal I.

AU - Felix, Janine F.

AU - Ward, James M.

AU - Guan, Weihua

AU - Richmond, Rebecca C.

AU - Brody, Jennifer A.

AU - Küpers, Leanne K.

AU - Baïz, Nour

AU - Håberg, Siri E.

AU - Smith, Jennifer A.

AU - Reese, Sarah E.

AU - Aslibekyan, Stella

AU - Hoyo, Cathrine

AU - Dhingra, Radhika

AU - Markunas, Christina A.

AU - Xu, Tao

AU - Reynolds, Lindsay M.

AU - Just, Allan C.

AU - Mandaviya, Pooja R.

AU - Ghantous, Akram

AU - Bennett, Brian D.

AU - Wang, Tianyuan

AU - Consortium, The Bios

AU - Bakulski, Kelly M.

AU - Melen, Erik

AU - Zhao, Shanshan

AU - Jin, Jianping

AU - Herceg, Zdenko

AU - Van Meurs, Joyce

AU - Taylor, Jack A.

AU - Baccarelli, Andrea A.

AU - Murphy, Susan K.

AU - Liu, Yongmei

AU - Munthe-Kaas, Monica Cheng

AU - Deary, Ian J.

AU - Nystad, Wenche

AU - Waldenberger, Melanie

AU - Annesi-Maesano, Isabella

AU - Conneely, Karen

AU - Jaddoe, Vincent W.V.

AU - Arnett, Donna

AU - Snieder, Harold

AU - Kardia, Sharon L.R.

AU - Relton, Caroline L.

AU - Ong, Ken K.

AU - Ewart, Susan

AU - Moreno-Macias, Hortensia

AU - Romieu, Isabelle

AU - Sotoodehnia, Nona

AU - Fornage, Myriam

AU - Motsinger-Reif, Alison

AU - Koppelman, Gerard H.

AU - Bustamante, Mariona

AU - Levy, Daniel

AU - London, Stephanie J.

N1 - Funding Information: 29Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA 30Department of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA 31Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands 32Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands 33Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France 34Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 35Westat, Durham, NC 27703, USA 36Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York City, NY 10032, USA 37Departments of Obstetrics & Gynecology & Pathology, Duke University School of Medicine, Durham, NC 27708, USA 38Department of Pediatrics, Oslo University Hospital, Oslo, Norway 39National Institute of Public Health, Oslo, Norway 40Centre for Cognitive Ageing & Cognitive Epidemiology, Edinburgh, UK 41Department of Psychology, University of Edinburgh, Edinburgh, UK 42Division of Mental & Physical Health, Norwegian Institute of Public Health, Oslo, Norway 43Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany 44Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA 45MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK 46Department of Paediatrics, University of Cambridge, Cambridge, UK 47Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824, USA 48Autonomous Metropolitan University Iztapalapa, Mexico City, Mexico 49Nutrition & Metabolism Section, International Agency for Research on Cancer, Lyon, France 50Center for Research on Population Health, National Institute of Public Health, Mexico 51Hubert Department of Global Health, Emory University, Atlanta, GA 30329, USA 52Institute of Molecular Medicine & Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225, USA 53Population Sciences Branch, National Heart, Lung, & Blood Institute, National Institutes of Health, Bethesda, MD 01702, USA *Author for correspondence: london2@niehs.nih.gov Funding Information: Funded by the Intramural Research Program of National Institutes of Health (National Institute of Environmental Health Sciences ZO1 ES49019) in addition to funding for individual authors and cohorts listed in the Supplementary Acknowledgements and Funding document. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: © 2019 Sinjini Sikdar.

PY - 2019/10

Y1 - 2019/10

N2 - Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

AB - Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

KW - cigarette smoking

KW - epigenetics

KW - infant

KW - maternal exposure

KW - methylation

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UR - http://www.scopus.com/inward/citedby.url?scp=85074118095&partnerID=8YFLogxK

U2 - 10.2217/epi-2019-0066

DO - 10.2217/epi-2019-0066

M3 - Article

C2 - 31536415

AN - SCOPUS:85074118095

VL - 11

SP - 1487

EP - 1500

IS - 13

ER -

Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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