Comparisons of plasma/serum micronutrients between Okinawan and oregonian elders: A pilot study

Hiroko H. Dodge; Yuriko Katsumata; Hidemi Todoriki; Shoutoku Yasura; D. Craig Willcox; Gene L. Bowman; Bradley Willcox; Scott Leonard; Aaron Clemons; Barry S. Oken; Jeffrey A. Kaye; Maret G. Traber

doi:10.1093/gerona/glq124

Comparisons of plasma/serum micronutrients between Okinawan and oregonian elders: A pilot study

Hiroko H. Dodge, Yuriko Katsumata, Hidemi Todoriki, Shoutoku Yasura, D. Craig Willcox, Gene L. Bowman, Bradley Willcox, Scott Leonard, Aaron Clemons, Barry S. Oken, Jeffrey A. Kaye, Maret G. Traber

Biostatistics

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating micronutrients cross-culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using similar inclusion criteria as the Oregon sample, from the Keys to Optimal Cognitive Aging Project. All participants were aged 85 years and older without cognitive impairment. We found that the Okinawan elders used fewer vitamin supplements but had similar levels of vitamin B12 and α-tocopherol, lower folate and γ-tocopherol, compared with Oregonian elders. That is, we did not find a uniform pattern of circulating micronutrients, suggesting that micronutrients other than those examined here or other lifestyle factors than nutrition could play an important role in achieving successful cognitive aging.

Original language	English
Pages (from-to)	1060-1067
Number of pages	8
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	65 A
Issue number	10
DOIs	https://doi.org/10.1093/gerona/glq124
State	Published - Oct 2010

Bibliographical note

Funding Information:
This study was supported by the National Institute on Aging ( K01AG023014 to H.H.D.), ( P30 AG08017 to J.A.K.), the National Center for Complementary and Alternative Medicine ( P50 AT00066 to J.A.K.), Linus Pauling Institute Research Grant (H.H.D.), Oregon Tax Check-off Grant (H.H.D.), the Center for Healthy Aging Research Pilot Grant at Oregon State University (H.H.D.), and Oregon Clinical and Translational Research Institution ( UL1 RR024140 ).

Keywords

Circulating micronutrients
Healthy cognitive aging
Okinawa
Oldest old
Oregon

ASJC Scopus subject areas

General Medicine

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Dodge, H. H., Katsumata, Y., Todoriki, H., Yasura, S., Willcox, D. C., Bowman, G. L., Willcox, B., Leonard, S., Clemons, A., Oken, B. S., Kaye, J. A., & Traber, M. G. (2010). Comparisons of plasma/serum micronutrients between Okinawan and oregonian elders: A pilot study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 65 A(10), 1060-1067. https://doi.org/10.1093/gerona/glq124

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title = "Comparisons of plasma/serum micronutrients between Okinawan and oregonian elders: A pilot study",

abstract = "Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating micronutrients cross-culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using similar inclusion criteria as the Oregon sample, from the Keys to Optimal Cognitive Aging Project. All participants were aged 85 years and older without cognitive impairment. We found that the Okinawan elders used fewer vitamin supplements but had similar levels of vitamin B12 and α-tocopherol, lower folate and γ-tocopherol, compared with Oregonian elders. That is, we did not find a uniform pattern of circulating micronutrients, suggesting that micronutrients other than those examined here or other lifestyle factors than nutrition could play an important role in achieving successful cognitive aging.",

keywords = "Circulating micronutrients, Healthy cognitive aging, Okinawa, Oldest old, Oregon",

author = "Dodge, {Hiroko H.} and Yuriko Katsumata and Hidemi Todoriki and Shoutoku Yasura and Willcox, {D. Craig} and Bowman, {Gene L.} and Bradley Willcox and Scott Leonard and Aaron Clemons and Oken, {Barry S.} and Kaye, {Jeffrey A.} and Traber, {Maret G.}",

note = "Funding Information: This study was supported by the National Institute on Aging ( K01AG023014 to H.H.D.), ( P30 AG08017 to J.A.K.), the National Center for Complementary and Alternative Medicine ( P50 AT00066 to J.A.K.), Linus Pauling Institute Research Grant (H.H.D.), Oregon Tax Check-off Grant (H.H.D.), the Center for Healthy Aging Research Pilot Grant at Oregon State University (H.H.D.), and Oregon Clinical and Translational Research Institution ( UL1 RR024140 ).",

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Dodge, HH, Katsumata, Y, Todoriki, H, Yasura, S, Willcox, DC, Bowman, GL, Willcox, B, Leonard, S, Clemons, A, Oken, BS, Kaye, JA & Traber, MG 2010, 'Comparisons of plasma/serum micronutrients between Okinawan and oregonian elders: A pilot study', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 65 A, no. 10, pp. 1060-1067. https://doi.org/10.1093/gerona/glq124

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T2 - A pilot study

AU - Dodge, Hiroko H.

AU - Katsumata, Yuriko

AU - Todoriki, Hidemi

AU - Yasura, Shoutoku

AU - Willcox, D. Craig

AU - Bowman, Gene L.

AU - Willcox, Bradley

AU - Leonard, Scott

AU - Clemons, Aaron

AU - Oken, Barry S.

AU - Kaye, Jeffrey A.

AU - Traber, Maret G.

N1 - Funding Information: This study was supported by the National Institute on Aging ( K01AG023014 to H.H.D.), ( P30 AG08017 to J.A.K.), the National Center for Complementary and Alternative Medicine ( P50 AT00066 to J.A.K.), Linus Pauling Institute Research Grant (H.H.D.), Oregon Tax Check-off Grant (H.H.D.), the Center for Healthy Aging Research Pilot Grant at Oregon State University (H.H.D.), and Oregon Clinical and Translational Research Institution ( UL1 RR024140 ).

PY - 2010/10

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N2 - Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating micronutrients cross-culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using similar inclusion criteria as the Oregon sample, from the Keys to Optimal Cognitive Aging Project. All participants were aged 85 years and older without cognitive impairment. We found that the Okinawan elders used fewer vitamin supplements but had similar levels of vitamin B12 and α-tocopherol, lower folate and γ-tocopherol, compared with Oregonian elders. That is, we did not find a uniform pattern of circulating micronutrients, suggesting that micronutrients other than those examined here or other lifestyle factors than nutrition could play an important role in achieving successful cognitive aging.

AB - Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating micronutrients cross-culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using similar inclusion criteria as the Oregon sample, from the Keys to Optimal Cognitive Aging Project. All participants were aged 85 years and older without cognitive impairment. We found that the Okinawan elders used fewer vitamin supplements but had similar levels of vitamin B12 and α-tocopherol, lower folate and γ-tocopherol, compared with Oregonian elders. That is, we did not find a uniform pattern of circulating micronutrients, suggesting that micronutrients other than those examined here or other lifestyle factors than nutrition could play an important role in achieving successful cognitive aging.

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KW - Healthy cognitive aging

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KW - Oldest old

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Comparisons of plasma/serum micronutrients between Okinawan and oregonian elders: A pilot study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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