Complete durable response of a pediatric anaplastic oligodendroglioma to temozolomide alone: Case report and review of literature

Caryn Sorge; Rong Li; Sumit Singh; Alyssa T. Reddy; David A. Solomon; Arie Perry; Gregory K. Friedman

doi:10.1002/pbc.26708

Complete durable response of a pediatric anaplastic oligodendroglioma to temozolomide alone: Case report and review of literature

Caryn Sorge
, Rong Li
, Sumit Singh
, Alyssa T. Reddy
, David A. Solomon
, Arie Perry
, Gregory K. Friedman

Pediatrics

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Anaplastic oligodendroglioma (AO) is rare in children. Treatment typically consists of varying combinations of surgery, chemotherapy, and radiotherapy. We present a pediatric case of frontal lobe AO with periventricular subcallosal extension and local leptomeningeal involvement. The isocitrate dehydrogenase (IDH) wild-type tumor was MGMT methylated and contained an ATRX mutation, BRAF alteration, and 1p/19q co-deletion; a combination of alterations mostly encountered in pediatric oligodendrogliomas. The patient underwent a near total resection and had a complete, durable response to temozolomide alone, suggesting that conservative management without radiation may be appropriate in some cases. We review the literature of this uncommon subtype of glioma in children.

Original language	English
Article number	e26708
Journal	Pediatric Blood and Cancer
Volume	64
Issue number	12
DOIs	https://doi.org/10.1002/pbc.26708
State	Published - Dec 2017

Bibliographical note

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.

Funding

Gregory K. Friedman, Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham 1600 7th Ave South Lowder 512, Birmingham, AL 35233. Email: [email protected] Grant sponsor: National Institutes of Health Director’s Early Independence Award; Grant number: DP5 OD021403. This work was supported in part by the National Institutes of Health

Funders	Funder number
National Institutes of Health (NIH)	DP5 OD021403
Foundation for the National Institutes of Health

Keywords

1p19q
children
codeletion
oligodendroglioma
pediatric
temozolomide

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1002/pbc.26708

Cite this

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title = "Complete durable response of a pediatric anaplastic oligodendroglioma to temozolomide alone: Case report and review of literature",

abstract = "Anaplastic oligodendroglioma (AO) is rare in children. Treatment typically consists of varying combinations of surgery, chemotherapy, and radiotherapy. We present a pediatric case of frontal lobe AO with periventricular subcallosal extension and local leptomeningeal involvement. The isocitrate dehydrogenase (IDH) wild-type tumor was MGMT methylated and contained an ATRX mutation, BRAF alteration, and 1p/19q co-deletion; a combination of alterations mostly encountered in pediatric oligodendrogliomas. The patient underwent a near total resection and had a complete, durable response to temozolomide alone, suggesting that conservative management without radiation may be appropriate in some cases. We review the literature of this uncommon subtype of glioma in children.",

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author = "Caryn Sorge and Rong Li and Sumit Singh and Reddy, \{Alyssa T.\} and Solomon, \{David A.\} and Arie Perry and Friedman, \{Gregory K.\}",

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year = "2017",

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doi = "10.1002/pbc.26708",

language = "English",

volume = "64",

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T2 - Case report and review of literature

AU - Sorge, Caryn

AU - Li, Rong

AU - Singh, Sumit

AU - Reddy, Alyssa T.

AU - Solomon, David A.

AU - Perry, Arie

AU - Friedman, Gregory K.

PY - 2017/12

Y1 - 2017/12

N2 - Anaplastic oligodendroglioma (AO) is rare in children. Treatment typically consists of varying combinations of surgery, chemotherapy, and radiotherapy. We present a pediatric case of frontal lobe AO with periventricular subcallosal extension and local leptomeningeal involvement. The isocitrate dehydrogenase (IDH) wild-type tumor was MGMT methylated and contained an ATRX mutation, BRAF alteration, and 1p/19q co-deletion; a combination of alterations mostly encountered in pediatric oligodendrogliomas. The patient underwent a near total resection and had a complete, durable response to temozolomide alone, suggesting that conservative management without radiation may be appropriate in some cases. We review the literature of this uncommon subtype of glioma in children.

AB - Anaplastic oligodendroglioma (AO) is rare in children. Treatment typically consists of varying combinations of surgery, chemotherapy, and radiotherapy. We present a pediatric case of frontal lobe AO with periventricular subcallosal extension and local leptomeningeal involvement. The isocitrate dehydrogenase (IDH) wild-type tumor was MGMT methylated and contained an ATRX mutation, BRAF alteration, and 1p/19q co-deletion; a combination of alterations mostly encountered in pediatric oligodendrogliomas. The patient underwent a near total resection and had a complete, durable response to temozolomide alone, suggesting that conservative management without radiation may be appropriate in some cases. We review the literature of this uncommon subtype of glioma in children.

KW - 1p19q

KW - children

KW - codeletion

KW - oligodendroglioma

KW - pediatric

KW - temozolomide

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UR - https://www.scopus.com/pages/publications/85022222803#tab=citedBy

U2 - 10.1002/pbc.26708

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AN - SCOPUS:85022222803

SN - 1545-5009

VL - 64

JO - Pediatric Blood and Cancer

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ER -

Complete durable response of a pediatric anaplastic oligodendroglioma to temozolomide alone: Case report and review of literature

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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