Complete response of CNS-involved olfactory neuroendocrine tumor using multimodal therapy

Gaurav Ahuja, Sandra Cuellar, Iffat Choudhry, Suman Setty, Mike Yao, J. Lee Villano

Research output: Contribution to journalArticlepeer-review


Introduction: Locally advanced tumors in the olfactory area commonly have central nervous system (CNS) involvement and are often incurable. Case Report: We report the treatment of a 25-year-old male patient who presented with a large, neuroendocrine tumor arising from the ethmoid complex. This locally invasive lesion extended beyond the orbits and into the anterior cranial fossa with associated intracranial involvement. An endoscopic nasal biopsy demonstrated a poorly differentiated neuroendocrine tumor. The patient was treated with 4 cycles of combination induction chemotherapy with irinotecan and cisplatin followed by radiation therapy with concurrent weekly cisplatin. He had a complete response to this therapy confirmed with biopsies that demonstrated no residual disease at 8 weeks after chemoradiotherapy. He remained disease free one and a half years following surgery. Conclusion: To our knowledge, this combination treatment approach has not been reported in the literature.

Original languageEnglish
Pages (from-to)119-121
Number of pages3
Issue number3
StatePublished - Mar 2008


  • Chemotherapy
  • Neuroendocrine tumor
  • Olfactory
  • Radiation therapy
  • Sinonasal

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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