Complex pathologies of angiotensin II-induced abdominal aortic aneurysms

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Angiotensin II (AngII) is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases. Subcutaneous infusion of AngII into mice induces the development of abdominal aortic aneurysms (AAAs). Like human AAAs, AngII-induced AAA tissues exhibit progressive changes and considerable heterogeneity. This complex pathology provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques. Therefore, while the mouse model of AngII-induced AAAs provides a salutary approach to studying the mechanisms of the evolution of AAAs in humans, meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased tissue.

Original languageEnglish
Pages (from-to)624-628
Number of pages5
JournalJournal of Zhejiang University: Science B
Volume12
Issue number8
DOIs
StatePublished - Aug 2011

Bibliographical note

Funding Information:
* Project (Nos. HL062846 and HL80100) supported by the National Institutes of Health of the United States of America © Zhejiang University and Springer-Verlag Berlin Heidelberg 2011

Keywords

  • Abdominal aortic aneurysms
  • Angiotensin II
  • Mouse
  • Pathologies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)
  • Veterinary (all)
  • Pharmacology, Toxicology and Pharmaceutics (all)

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