Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities

Nishad Thamban Chandrika, Sylvie Garneau-Tsodikova

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

A systematic analysis of all synthetic and chemoenzymatic methodologies for the preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) reported in the scientific literature up to 2017 is presented. This comprehensive analysis of derivatization/generation of novel aminoglycosides and their conjugates is divided based on the types of modifications used to make the new derivatives. Both the chemical strategies utilized and the biological results observed are covered. Structure-activity relationships based on different synthetic modifications along with their implications for activity and ability to avoid resistance against different microorganisms are also presented.

Original languageEnglish
Pages (from-to)1189-1249
Number of pages61
JournalChemical Society Reviews
Volume47
Issue number4
DOIs
StatePublished - Feb 21 2018

Bibliographical note

Funding Information:
This work was supported by a grant from the National Institutes of Health AI090048 (to S. G.-T.) and startup funds from the College of Pharmacy at the University of Kentucky (to S. G.-T.). We thank all of those working in the field of aminoglycosides and apologize to those whose work was not cited due to the scope of this review.

Publisher Copyright:
© 2018 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Chemistry (all)

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