A systematic analysis of all synthetic and chemoenzymatic methodologies for the preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) reported in the scientific literature up to 2017 is presented. This comprehensive analysis of derivatization/generation of novel aminoglycosides and their conjugates is divided based on the types of modifications used to make the new derivatives. Both the chemical strategies utilized and the biological results observed are covered. Structure-activity relationships based on different synthetic modifications along with their implications for activity and ability to avoid resistance against different microorganisms are also presented.
|Number of pages||61|
|Journal||Chemical Society Reviews|
|State||Published - Feb 21 2018|
Bibliographical noteFunding Information:
This work was supported by a grant from the National Institutes of Health AI090048 (to S. G.-T.) and startup funds from the College of Pharmacy at the University of Kentucky (to S. G.-T.). We thank all of those working in the field of aminoglycosides and apologize to those whose work was not cited due to the scope of this review.
© 2018 The Royal Society of Chemistry.
ASJC Scopus subject areas
- Chemistry (all)