Concurrent choice for social interaction and amphetamine using conditioned place preference in rats: Effects of age and housing condition

Justin R. Yates, Joshua S. Beckmann, Andrew C. Meyer, Michael T. Bardo

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Background: Social interaction can serve as a natural reward that attenuates drug reward in rats; however, it is unknown if age or housing conditions alter the choice between social interaction and drug. Methods: Individually- and pair-housed adolescent and adult male rats were tested using conditioned place preference (CPP) in separate experiments in which: (1) social interaction was conditioned against no social interaction; (2) amphetamine (AMPH; 1. mg/kg, s.c.) was conditioned against saline; or (3) social interaction was conditioned against AMPH. Results: Social interaction CPP was obtained only in individually-housed adolescents, whereas AMPH CPP was obtained in both individually-housed adolescents and adults; however, the effect of AMPH was not statistically significant in pair-housed adults. When allowed to choose concurrently between compartments paired with either social interaction or AMPH, individually-housed adolescents preferred the compartment paired with social interaction, whereas pair-housed adolescents preferred the compartment paired with AMPH. Regardless of housing condition, adults showed a similar preference for the compartments paired with either social interaction or AMPH. Conclusions: Although some caution is needed in interpreting cross-experiment comparisons, the overall results suggest that individually-housed adolescents were most sensitive to the rewarding effect of social interaction, and this hypersensitivity to social reward effectively competed with AMPH reward.

Original languageEnglish
Pages (from-to)240-246
Number of pages7
JournalDrug and Alcohol Dependence
Volume129
Issue number3
DOIs
StatePublished - May 1 2013

Keywords

  • Adolescence
  • Amphetamine
  • Concurrent choice
  • Conditioned place preference
  • Development
  • Differential housing
  • Social interaction

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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