Concurrent measurements of neurochemical and electrophysiological activity with microelectrode arrays: New perspectives for constant potential amperometry

Ana Ledo, Cátia F. Lourenço, João Laranjinha, Greg A. Gerhardt, Rui M. Barbosa

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Our current understanding of neurotransmission and neuromodulation stands to gain from concurrent electrochemical and electrophysiological measurements, which have been attempted since the introduction of in vivo electrochemical techniques. Dual in vivo recordings have evolved from parallel approaches using two distinct microelectrodes towards serial strategies encompassing “time-sharing” between two independent recording systems while using a single microelectrode. More recently, fast sampling amperometry has been demonstrated to allow concurrent measurement of rapid neurochemical and electrophysiological events using a single sensor and recording system. This is supported by the fact that the high-frequency component of an amperometric recording (>1 Hz) resembles the local field potential while the low frequency component (<1 Hz) reflects the electrochemical signal resulting from the oxidation or reduction of electroactive species present in the milieu. This opens new avenues for constant potential amperometry, widening the application of this seamless electrochemical technique.

Original languageEnglish
Pages (from-to)129-140
Number of pages12
JournalCurrent Opinion in Electrochemistry
Volume12
DOIs
StatePublished - Dec 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier B.V.

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry

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