Conditioned taste aversion induced by fluoxetine

Mark A. Prendergast, Shelton E. Hendricks, David P. Yells, Scott Balogh

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The present study assessed the ability of the serotonin reuptake inhibitor fluoxetine (FLX) and lithium chloride (LiCl) to induce conditioned taste aversion (CTA) to a novel 20% sucrose solution. FLX (2, 5, or 8 mg/kg) or LiCl (10 mg/kg) was administered 30 min after an initial exposure to the solution. A single-bottle test of CTA 24 h after the initial exposure indicated that rats that received FLX, at any dose, or LiCl consumed significantly less solution than did those that received a vehicle treatment following the initial exposure. To examine the possibility that decreased consumption during the CTA test exposure was associated with lasting hypophagia and/or hypodipsia induced by FLX, separate groups of rats, without any prior exposure to the solution, were administered FLX (2, 5, or 8 mg/kg) and given access 24 h later to a 20% sucrose solution. FLX failed to suppress consumption of the solution at any dose. These data suggest that FLX induces an aversive drug state in rats, similar to that induced by LiCl, which serves as a potent conditioned stimulus in CTA. In addition, this CTA is independent of FLX-induced hypophagia and/or hypodipsia. The relevance of these results to the study of hypophagia induced by FLX administration is discussed.

Original languageEnglish
Pages (from-to)311-315
Number of pages5
JournalPhysiology and Behavior
Volume60
Issue number1
DOIs
StatePublished - Jul 1996

Bibliographical note

Funding Information:
The authors thank Eli Lilly Laboratories for their generous donation of fluoxetine HCI. In addition, we thank the members of the University of Nebraska Medical Center Psychopharmacology Research Center for their assistance in the preparation of this manuscript. Portions of this work were supported by a grant (NSF #OSR92-55225) awarded to the Nebraska Behavioral Biology Group.

Keywords

  • Aversion
  • Conditioning
  • Feeding
  • Fluoxetine

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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