Consensus translational initiation sites of marine invertebrate phyla

Raj V. Mankad, Alexander A. Gimelbrant, Timothy S. Mcclintock

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The efficiency of translational initiation depends upon the sequence context surrounding the AUG codon (1, 2, 3). A purine at position -3 contributes critically to context, but other neighboring nucleotides are also important. Nucleotide frequencies at these neighboring positions vary among distant taxa (4, 5). We have analyzed the translational initiation sites of cnidarian, echinoderm, molluscan, annelid, and crustacean sequences in nucleotide sequence databases. These taxa conform to the pattern of a strong preference for a purine at -3, but the frequencies of nucleotides at neighboring positions are characteristic for each taxon. The consensus translational initiation sequences of the marine invertebrate taxa are also different from those of vertebrates and single-celled eukaryotes. These consensus sequences are useful guides for predicting translational initiation sites in cDNA clones.

Original languageEnglish
Pages (from-to)251-254
Number of pages4
JournalBiological Bulletin
Issue number3
StatePublished - 1998

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences


Dive into the research topics of 'Consensus translational initiation sites of marine invertebrate phyla'. Together they form a unique fingerprint.

Cite this