Construction of low‐variability litters of preweaning mice

Herman T. Epstein, Larry B. Goldstein

Research output: Contribution to journalArticlepeer-review


Mouse litter variation at weaning stems from a combination of genetic makeup, intrauterine experience, and postnatal maternal care. The 1st 2 factors may be matched at birth by making up separate litters out of littermate pairs whose birth weights are equal (± .02 g). Maternal competence may be matched by exchanging the mothers between the 2 cages each day. These tactices yield litters at weaning whose variability has been very much reduced. The range of litter‐average body weights has been reduced from about 40% to about 5% and the range of litter‐average brain weights has been reduced from about 15% to about 1‐2%.

Original languageEnglish
Pages (from-to)575-577
Number of pages3
JournalDevelopmental Psychobiology
Issue number6
StatePublished - Nov 1977

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Developmental Neuroscience
  • Developmental Biology
  • Behavioral Neuroscience


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