Contrasting mechanisms of stem cell maintenance in Drosophila

Susan M.W. Harrison, Douglas A. Harrison

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Stem cells are self-renewing multipotent cells essential for development or homeostasis of many tissues. Stem cell populations can be found in most multicellular plants and animals. The mechanisms by which these populations are maintained are diverse, utilizing both intrinsic and extrinsic factors to regulate cell division and differentiation. The genetic tools of the fruitfly, Drosophila melanogaster, have permitted detailed characterization of two stem cell populations. In this review, we will examine these contrasting stem cell model systems from Drosophila and their relevance to stem cell populations in other organisms.

Original languageEnglish
Pages (from-to)518-533
Number of pages16
JournalSeminars in Cell and Developmental Biology
Volume17
Issue number4
DOIs
StatePublished - Aug 2006

Bibliographical note

Funding Information:
D.A.H.'s lab is supported by the National Science Foundation (IBN-0318776).

Keywords

  • Gametogenesis
  • Neurogenesis
  • Niche
  • Stem cells

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Contrasting mechanisms of stem cell maintenance in Drosophila'. Together they form a unique fingerprint.

Cite this