Abstract
Stem cells are self-renewing multipotent cells essential for development or homeostasis of many tissues. Stem cell populations can be found in most multicellular plants and animals. The mechanisms by which these populations are maintained are diverse, utilizing both intrinsic and extrinsic factors to regulate cell division and differentiation. The genetic tools of the fruitfly, Drosophila melanogaster, have permitted detailed characterization of two stem cell populations. In this review, we will examine these contrasting stem cell model systems from Drosophila and their relevance to stem cell populations in other organisms.
Original language | English |
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Pages (from-to) | 518-533 |
Number of pages | 16 |
Journal | Seminars in Cell and Developmental Biology |
Volume | 17 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2006 |
Bibliographical note
Funding Information:D.A.H.'s lab is supported by the National Science Foundation (IBN-0318776).
Keywords
- Gametogenesis
- Neurogenesis
- Niche
- Stem cells
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology