Control of complex behavior by astrocytes and microglia

P. I. Ortinski, K. J. Reissner, J. Turner, T. A. Anderson, A. Scimemi

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Evidence that glial cells influence behavior has been gaining a steady foothold in scientific literature. Out of the five main subtypes of glial cells in the brain, astrocytes and microglia have received an outsized share of attention with regard to shaping a wide spectrum of behavioral phenomena and there is growing appreciation that the signals intrinsic to these cells as well as their interactions with surrounding neurons reflect behavioral history in a brain region-specific manner. Considerable regional diversity of glial cell phenotypes is beginning to be recognized and may contribute to behavioral outcomes arising from circuit-specific computations within and across discrete brain nuclei. Here, we summarize current knowledge on the impact of astrocyte and microglia activity on behavioral outcomes, with a specific focus on brain areas relevant to higher cognitive control, reward-seeking, and circadian regulation.

Original languageEnglish
Article number104651
JournalNeuroscience and Biobehavioral Reviews
StatePublished - Jun 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Ltd

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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