Controllable in situ synthesis of magnetite coated silica-core water-dispersible hybrid nanomaterials

Haiou Qu, Sheng Tong, Kejing Song, Hui Ma, Gang Bao, Seth Pincus, Weilie Zhou, Charles O'Connor

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Magnetite nanoparticle coated silica (Fe3O4@SiO 2) hybrid nanomaterials hold an important position in the fields of cell imaging and drug delivery. Here we report a large scale synthetic procedure that allows attachment of magnetite nanoparticles onto a silica surface in situ. Many different silica nanomaterials such as Stöber silica nanospheres, mesoporous silica nanoparticles, and hollow silica nanotubes have been coated with a high density layer of water-dispersible magnetite nanoparticles. The size and attachment efficiency of the magnetite nanoparticle can be well tuned by adjusting the precursor concentration and reflux time. The functionalization of Fe3O4@SiO2 nanoparticles with dye molecules and biocompatible polymers impart optical imaging modality and good colloidal stability in either buffer solution or serum. The functionalized materials also exhibited strong potential as negative contrast agents in T2 weighted magnetic resonance imaging.

Original languageEnglish
Pages (from-to)10573-10578
Number of pages6
Issue number33
StatePublished - Aug 20 2013

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


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