Controlled release strategies for modulating immune responses to promote tissue regeneration

Courtney M. Dumont, Jonghyuck Park, Lonnie D. Shea

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Advances in the field of tissue engineering have enhanced the potential of regenerative medicine, yet the efficacy of these strategies remains incomplete, and is limited by the innate and adaptive immune responses. The immune response associated with injury or disease combined with that mounted to biomaterials, transplanted cells, proteins, and gene therapies vectors can contribute to the inability to fully restore tissue function. Blocking immune responses such as with anti-inflammatory or immunosuppressive agents are either ineffective, as the immune response contributes significantly to regeneration, or have significant side effects. This review describes targeted strategies to modulate the immune response in order to limit tissue damage following injury, promote an anti-inflammatory environment that leads to regeneration, and induce antigen (Ag)-specific tolerance that can target degenerative diseases that destroy tissues and promote engraftment of transplanted cells. Focusing on targeted immuno-modulation, we describe local delivery techniques to sites of inflammation as well as systemic approaches that preferentially target subsets of immune populations.

Original languageEnglish
Pages (from-to)155-166
Number of pages12
JournalJournal of Controlled Release
Volume219
DOIs
StatePublished - Dec 10 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.

Keywords

  • Biomaterials
  • Cell transplantation
  • Gene delivery
  • Immune modulation
  • Immune system
  • Nanoparticles
  • Stem cells
  • T cells
  • Tissue engineering

ASJC Scopus subject areas

  • Pharmaceutical Science

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