Controlled synergistic delivery of paclitaxel and heat from poly(β-amino ester)/iron oxide-based hydrogel nanocomposites

Samantha A. Meenach, Chinedu G. Otu, Kimberly W. Anderson, J. Zach Hilt

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Poly(β-amino ester) (PBAE) biodegradable hydrogels were investigated for potential combined chemotherapeutic and heat delivery in the synergistic treatment of cancer. Hyperthermia, the heating of cancerous tissue from 41 to 45 °C, increases the efficacy of conventional cancer therapies such as irradiation and chemotherapy. The hydrogel nanocomposites in this work provide a drug delivery vehicle (via the biodegradable PBAE polymer network) and the ability to be heated remotely upon exposure to an alternating magnetic field (via iron oxide nanoparticles incorporated into the hydrogel matrix). PBAE macromers composed of poly(ethylene glycol) (N = 400) diacrylate (PEG400DA) or diethylene glycol diacrylate (DEGDA) with isobutylamine (IBA) were synthesized. Hydrogel nanocomposites were fabricated via free-radical polymerization to form a bulk hydrogel matrix entrapping both iron oxide nanoparticles and paclitaxel. The 2EG-IBA hydrogel exhibited complete degradation after approximately 7 weeks whereas the 9EG-IBA hydrogel degraded completely in 11 h. The hydrogels heated upon exposure to an alternating magnetic field throughout the degradation process. Additionally, the cytotoxicity of the degradation products was evaluated. Paclitaxel release was controlled via bulk degradation of the hydrogels. The tailorability of these nanocomposites makes them solid candidates for the synergistic treatment of cancer.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume427
Issue number2
DOIs
StatePublished - May 10 2012

Bibliographical note

Funding Information:
Partial funding for this research was provided by the Kentucky Science and Engineering Foundation (Award Number KSEF0148-502-06-188). S. Meenach and J. Shapiro acknowledge the Engineered Bioactive Interfaces & Devices NSF IGERT (Award Number DGE-0653710) and NSF IGERT REU (Award Number EEC-0851716) for providing partial funding for this research, respectively.

Keywords

  • Cancer
  • Hydrogel
  • Hyperthermia
  • Nanocomposites
  • Paclitaxel
  • Poly(β-amino ester) (PBAE)

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint

Dive into the research topics of 'Controlled synergistic delivery of paclitaxel and heat from poly(β-amino ester)/iron oxide-based hydrogel nanocomposites'. Together they form a unique fingerprint.

Cite this