Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms

Xiaofeng Chen, Hong Lu, Debra L. Rateri, Lisa A. Cassis, Alan Daugherty

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

Angiotensin II (AngII) has been invoked as a principal mediator for the development and progression of both thoracic and abdominal aortic aneurysms. While there is consistency in experimental and clinical studies that overactivation of the renin angiotensin system promotes aortic aneurysm development, there are many unknowns regarding the mechanistic basis underlying AngII-induced aneurysms. Interactions of AngII with TGF-β in both thoracic and abdominal aortic aneurysms have been the focus of recent studies. While these studies have demonstrated profound effects of manipulating TGF-β activity on AngII-induced aortic aneurysms, they have also led to more questions regarding the interactions between AngII and this multifunctional cytokine. This review compiled the recent literature to provide insights into understanding the potentially complex interactions between AngII and TGF-β in the development of aortic aneurysms.

Original languageEnglish
Pages (from-to)180-185
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume13
Issue number2
DOIs
StatePublished - Apr 2013

Bibliographical note

Funding Information:
The authors’ research work was supported by funding from the National Institutes of Health ( HL062846 and HL107319 ). Xiaofeng Chen's research was also supported by a McKusick Fellowship grant from the National Marfan Foundation (NMF) .

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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