Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms

Xiaofeng Chen; Hong Lu; Debra L. Rateri; Lisa A. Cassis; Alan Daugherty

doi:10.1016/j.coph.2013.01.002

Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms

Xiaofeng Chen, Hong Lu, Debra L. Rateri, Lisa A. Cassis, Alan Daugherty

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

Angiotensin II (AngII) has been invoked as a principal mediator for the development and progression of both thoracic and abdominal aortic aneurysms. While there is consistency in experimental and clinical studies that overactivation of the renin angiotensin system promotes aortic aneurysm development, there are many unknowns regarding the mechanistic basis underlying AngII-induced aneurysms. Interactions of AngII with TGF-β in both thoracic and abdominal aortic aneurysms have been the focus of recent studies. While these studies have demonstrated profound effects of manipulating TGF-β activity on AngII-induced aortic aneurysms, they have also led to more questions regarding the interactions between AngII and this multifunctional cytokine. This review compiled the recent literature to provide insights into understanding the potentially complex interactions between AngII and TGF-β in the development of aortic aneurysms.

Original language	English
Pages (from-to)	180-185
Number of pages	6
Journal	Current Opinion in Pharmacology
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/j.coph.2013.01.002
State	Published - Apr 2013

Bibliographical note

Funding Information:
The authors’ research work was supported by funding from the National Institutes of Health ( HL062846 and HL107319 ). Xiaofeng Chen's research was also supported by a McKusick Fellowship grant from the National Marfan Foundation (NMF) .

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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title = "Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms",

abstract = "Angiotensin II (AngII) has been invoked as a principal mediator for the development and progression of both thoracic and abdominal aortic aneurysms. While there is consistency in experimental and clinical studies that overactivation of the renin angiotensin system promotes aortic aneurysm development, there are many unknowns regarding the mechanistic basis underlying AngII-induced aneurysms. Interactions of AngII with TGF-β in both thoracic and abdominal aortic aneurysms have been the focus of recent studies. While these studies have demonstrated profound effects of manipulating TGF-β activity on AngII-induced aortic aneurysms, they have also led to more questions regarding the interactions between AngII and this multifunctional cytokine. This review compiled the recent literature to provide insights into understanding the potentially complex interactions between AngII and TGF-β in the development of aortic aneurysms.",

author = "Xiaofeng Chen and Hong Lu and Rateri, {Debra L.} and Cassis, {Lisa A.} and Alan Daugherty",

note = "Funding Information: The authors{\textquoteright} research work was supported by funding from the National Institutes of Health ( HL062846 and HL107319 ). Xiaofeng Chen's research was also supported by a McKusick Fellowship grant from the National Marfan Foundation (NMF) .",

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language = "English",

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T1 - Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms

AU - Chen, Xiaofeng

AU - Lu, Hong

AU - Rateri, Debra L.

AU - Cassis, Lisa A.

AU - Daugherty, Alan

N1 - Funding Information: The authors’ research work was supported by funding from the National Institutes of Health ( HL062846 and HL107319 ). Xiaofeng Chen's research was also supported by a McKusick Fellowship grant from the National Marfan Foundation (NMF) .

PY - 2013/4

Y1 - 2013/4

N2 - Angiotensin II (AngII) has been invoked as a principal mediator for the development and progression of both thoracic and abdominal aortic aneurysms. While there is consistency in experimental and clinical studies that overactivation of the renin angiotensin system promotes aortic aneurysm development, there are many unknowns regarding the mechanistic basis underlying AngII-induced aneurysms. Interactions of AngII with TGF-β in both thoracic and abdominal aortic aneurysms have been the focus of recent studies. While these studies have demonstrated profound effects of manipulating TGF-β activity on AngII-induced aortic aneurysms, they have also led to more questions regarding the interactions between AngII and this multifunctional cytokine. This review compiled the recent literature to provide insights into understanding the potentially complex interactions between AngII and TGF-β in the development of aortic aneurysms.

AB - Angiotensin II (AngII) has been invoked as a principal mediator for the development and progression of both thoracic and abdominal aortic aneurysms. While there is consistency in experimental and clinical studies that overactivation of the renin angiotensin system promotes aortic aneurysm development, there are many unknowns regarding the mechanistic basis underlying AngII-induced aneurysms. Interactions of AngII with TGF-β in both thoracic and abdominal aortic aneurysms have been the focus of recent studies. While these studies have demonstrated profound effects of manipulating TGF-β activity on AngII-induced aortic aneurysms, they have also led to more questions regarding the interactions between AngII and this multifunctional cytokine. This review compiled the recent literature to provide insights into understanding the potentially complex interactions between AngII and TGF-β in the development of aortic aneurysms.

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JO - Current Opinion in Pharmacology

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Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms

Abstract

Bibliographical note

ASJC Scopus subject areas

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