Copper-catalyzed guanidinylation of aryl iodides: The formation of N,N′-disubstituted guanidines

Michelle Cortes-Salva; Be Lan Nguyen; Javier Cuevas; Keith R. Pennypacker; Jon C. Antilla

doi:10.1021/ol1002175

Copper-catalyzed guanidinylation of aryl iodides: The formation of N,N′-disubstituted guanidines

Michelle Cortes-Salva, Be Lan Nguyen, Javier Cuevas, Keith R. Pennypacker, Jon C. Antilla

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

"Chemical Equation Presented" A copper-catalyzed cross-coupling reaction of guanidine nitrate with aryl iodides was used for the formation of N,N′-disubstituted guanidines to be used as potential therapeutics for strokes. A relatively inexpensive commercially available guanidine salt and a series of aryl iodides together with copper iodide and N,N-diethylsalicylamide as an efficient catalyst/1 igand system provided a simple diarylation procedure.

Original language	English
Pages (from-to)	1316-1319
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	6
DOIs	https://doi.org/10.1021/ol1002175
State	Published - Mar 19 2010

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol1002175

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abstract = "{"}Chemical Equation Presented{"} A copper-catalyzed cross-coupling reaction of guanidine nitrate with aryl iodides was used for the formation of N,N′-disubstituted guanidines to be used as potential therapeutics for strokes. A relatively inexpensive commercially available guanidine salt and a series of aryl iodides together with copper iodide and N,N-diethylsalicylamide as an efficient catalyst/1 igand system provided a simple diarylation procedure.",

author = "Michelle Cortes-Salva and Nguyen, \{Be Lan\} and Javier Cuevas and Pennypacker, \{Keith R.\} and Antilla, \{Jon C.\}",

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T2 - The formation of N,N′-disubstituted guanidines

AU - Cortes-Salva, Michelle

AU - Nguyen, Be Lan

AU - Cuevas, Javier

AU - Pennypacker, Keith R.

AU - Antilla, Jon C.

PY - 2010/3/19

Y1 - 2010/3/19

N2 - "Chemical Equation Presented" A copper-catalyzed cross-coupling reaction of guanidine nitrate with aryl iodides was used for the formation of N,N′-disubstituted guanidines to be used as potential therapeutics for strokes. A relatively inexpensive commercially available guanidine salt and a series of aryl iodides together with copper iodide and N,N-diethylsalicylamide as an efficient catalyst/1 igand system provided a simple diarylation procedure.

AB - "Chemical Equation Presented" A copper-catalyzed cross-coupling reaction of guanidine nitrate with aryl iodides was used for the formation of N,N′-disubstituted guanidines to be used as potential therapeutics for strokes. A relatively inexpensive commercially available guanidine salt and a series of aryl iodides together with copper iodide and N,N-diethylsalicylamide as an efficient catalyst/1 igand system provided a simple diarylation procedure.

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U2 - 10.1021/ol1002175

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JO - Organic Letters

JF - Organic Letters

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ER -

Copper-catalyzed guanidinylation of aryl iodides: The formation of N,N′-disubstituted guanidines

Abstract

ASJC Scopus subject areas

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