Copper, iron and zinc in Alzheimer's disease senile plaques

M. A. Lovell; J. D. Robertson; W. J. Teesdale; J. L. Campbell; W. R. Markesbery

doi:10.1016/S0022-510X(98)00092-6

Copper, iron and zinc in Alzheimer's disease senile plaques

M. A. Lovell, J. D. Robertson, W. J. Teesdale, J. L. Campbell, W. R. Markesbery

Research output: Contribution to journal › Article › peer-review

1941 Scopus citations

Abstract

Concentrations of copper (Cu), iron (Fe) and zinc (Zn) were measured in the rims and cores of senile plaques (SP) and in the neuropil of the amygdala of nine Alzheimer's disease (AD) patients and in the neuropil of the amygdala of five neurologically normal control subjects using micro particle-induced X-ray emission (micro-PIXE). Comparison of SP rim and core values revealed no significant differences between levels of Cu, Fe or Zn. Zinc and Fe in SP rims and cores were significantly elevated in AD compared with AD neuropil (P<0.05). Copper was significantly elevated (P<0.05) in the rim of SP compared with AD neuropil. Comparison of AD and control neuropil revealed a significant (P<0.05) elevation of Zn in AD subjects. The elevation of these elements in SP in AD is of interest in light of the observation that Cu, Fe and particularly Zn, can accelerate aggregation of amyloid beta peptide.

Original language	English
Pages (from-to)	47-52
Number of pages	6
Journal	Journal of the Neurological Sciences
Volume	158
Issue number	1
DOIs	https://doi.org/10.1016/S0022-510X(98)00092-6
State	Published - Jun 11 1998

Bibliographical note

Funding Information:
The authors would like to express their appreciation to Ms Ela Patel for tissue sectioning and immunostaining, to Ms Paula Thomason, Mr Brian Hallahan, and Mr Don Rightmyer for assistance in manuscript preparation and to Mr Stuart Ryan for his assistance in sample preparation. Funding for this work was provided in part by NIH grants 2-PO1-AG05119, 5-P50 AG0514 and by a grant from the Abercrombie Foundation.

Funding

The authors would like to express their appreciation to Ms Ela Patel for tissue sectioning and immunostaining, to Ms Paula Thomason, Mr Brian Hallahan, and Mr Don Rightmyer for assistance in manuscript preparation and to Mr Stuart Ryan for his assistance in sample preparation. Funding for this work was provided in part by NIH grants 2-PO1-AG05119, 5-P50 AG0514 and by a grant from the Abercrombie Foundation.

Funders	Funder number
National Institutes of Health (NIH)	5-P50 AG0514
National Institute on Aging	P01AG005119
Abercrombie Foundation

Keywords

Alzheimer's disease
Copper
Iron
Micro-PIXE analysis
Senile plaques
Zinc

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/S0022-510X(98)00092-6

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title = "Copper, iron and zinc in Alzheimer's disease senile plaques",

abstract = "Concentrations of copper (Cu), iron (Fe) and zinc (Zn) were measured in the rims and cores of senile plaques (SP) and in the neuropil of the amygdala of nine Alzheimer's disease (AD) patients and in the neuropil of the amygdala of five neurologically normal control subjects using micro particle-induced X-ray emission (micro-PIXE). Comparison of SP rim and core values revealed no significant differences between levels of Cu, Fe or Zn. Zinc and Fe in SP rims and cores were significantly elevated in AD compared with AD neuropil (P<0.05). Copper was significantly elevated (P<0.05) in the rim of SP compared with AD neuropil. Comparison of AD and control neuropil revealed a significant (P<0.05) elevation of Zn in AD subjects. The elevation of these elements in SP in AD is of interest in light of the observation that Cu, Fe and particularly Zn, can accelerate aggregation of amyloid beta peptide.",

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author = "Lovell, {M. A.} and Robertson, {J. D.} and Teesdale, {W. J.} and Campbell, {J. L.} and Markesbery, {W. R.}",

note = "Funding Information: The authors would like to express their appreciation to Ms Ela Patel for tissue sectioning and immunostaining, to Ms Paula Thomason, Mr Brian Hallahan, and Mr Don Rightmyer for assistance in manuscript preparation and to Mr Stuart Ryan for his assistance in sample preparation. Funding for this work was provided in part by NIH grants 2-PO1-AG05119, 5-P50 AG0514 and by a grant from the Abercrombie Foundation.",

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AU - Markesbery, W. R.

N1 - Funding Information: The authors would like to express their appreciation to Ms Ela Patel for tissue sectioning and immunostaining, to Ms Paula Thomason, Mr Brian Hallahan, and Mr Don Rightmyer for assistance in manuscript preparation and to Mr Stuart Ryan for his assistance in sample preparation. Funding for this work was provided in part by NIH grants 2-PO1-AG05119, 5-P50 AG0514 and by a grant from the Abercrombie Foundation.

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N2 - Concentrations of copper (Cu), iron (Fe) and zinc (Zn) were measured in the rims and cores of senile plaques (SP) and in the neuropil of the amygdala of nine Alzheimer's disease (AD) patients and in the neuropil of the amygdala of five neurologically normal control subjects using micro particle-induced X-ray emission (micro-PIXE). Comparison of SP rim and core values revealed no significant differences between levels of Cu, Fe or Zn. Zinc and Fe in SP rims and cores were significantly elevated in AD compared with AD neuropil (P<0.05). Copper was significantly elevated (P<0.05) in the rim of SP compared with AD neuropil. Comparison of AD and control neuropil revealed a significant (P<0.05) elevation of Zn in AD subjects. The elevation of these elements in SP in AD is of interest in light of the observation that Cu, Fe and particularly Zn, can accelerate aggregation of amyloid beta peptide.

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KW - Zinc

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Copper, iron and zinc in Alzheimer's disease senile plaques

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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