TY - JOUR
T1 - Copy number variations associated with obesity-related traits in African Americans
T2 - A joint analysis between GENOA and HyperGEN
AU - Zhao, Wei
AU - Wineinger, Nathan E.
AU - Tiwari, Hemant K.
AU - Mosley, Thomas H.
AU - Broeckel, Ulrich
AU - Arnett, Donna K.
AU - Kardia, Sharon L.R.
AU - Kabagambe, Edmond K.
AU - Sun, Yan V.
PY - 2012/12
Y1 - 2012/12
N2 - Obesity is a highly heritable trait and a growing public health problem. African Americans (AAs) are a genetically diverse, yet understudied population with a high prevalence of obesity (BMI >30 kg/m 2). Recent studies based upon single-nucleotide polymorphisms (SNPs) have identified genetic markers associated with obesity. However, a large proportion of the heritability of obesity remains unexplained. Copy number variation (CNV) has been cited as a possible source of missing heritability in common diseases such as obesity. We conducted a CNV genome-wide association study of BMI in two African-American cohorts from Genetic Epidemiology Network of Arteriopathy (GENOA) and Hypertension Genetic Epidemiology Network (HyperGEN). We performed independent and identical association analyses in each study, then combined the results in a meta-analysis. We identified three CNVs associated with BMI, obesity, and other obesity-related traits after adjusting for multiple testing. These CNVs overlap the PARK2, GYPA, and SGCZ genes. Our results suggest that CNV may play a role in the etiology of obesity in AAs.
AB - Obesity is a highly heritable trait and a growing public health problem. African Americans (AAs) are a genetically diverse, yet understudied population with a high prevalence of obesity (BMI >30 kg/m 2). Recent studies based upon single-nucleotide polymorphisms (SNPs) have identified genetic markers associated with obesity. However, a large proportion of the heritability of obesity remains unexplained. Copy number variation (CNV) has been cited as a possible source of missing heritability in common diseases such as obesity. We conducted a CNV genome-wide association study of BMI in two African-American cohorts from Genetic Epidemiology Network of Arteriopathy (GENOA) and Hypertension Genetic Epidemiology Network (HyperGEN). We performed independent and identical association analyses in each study, then combined the results in a meta-analysis. We identified three CNVs associated with BMI, obesity, and other obesity-related traits after adjusting for multiple testing. These CNVs overlap the PARK2, GYPA, and SGCZ genes. Our results suggest that CNV may play a role in the etiology of obesity in AAs.
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U2 - 10.1038/oby.2012.162
DO - 10.1038/oby.2012.162
M3 - Article
C2 - 22836685
AN - SCOPUS:84870302695
SN - 1930-7381
VL - 20
SP - 2431
EP - 2437
JO - Obesity
JF - Obesity
IS - 12
ER -
