Coregulator interactions with the thyroid hormone receptor

Jamie M.R. Moore, R. Kiplin Guy

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


The thyroid hormone receptor (TR) directly regulates the transcription of thyroid hormone-responsive genes in response to changing levels of thyroid hormone. Mechanistically TR utilizes a complex set of binding interactions, with hormone, response elements, and coregulatory proteins, to provide specific local control of patterns of transcriptional response that are partially responsible for inducing the tissue-selective responses to the circulating hormone. One of the apparently dominant phenomena in the regulation of thyroid hormone responses is the protein interactions between TR and its coregulators. This review summarizes the current state of knowledge with respect to the identity of these coregulators, their interaction with TR, and the consequences of those interactions.

Original languageEnglish
Pages (from-to)475-482
Number of pages8
JournalMolecular and Cellular Proteomics
Issue number4
StatePublished - Apr 2005

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Molecular Biology


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