Corneal allograft rejection following immunization

Thomas L. Steinemann, Bruce H. Koffler, C. Darrell Jennings

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Five patients developed corneal allograft rejection after immunization. One patient, a 33-year-old woman, received a tetanus toxoid booster nine months after a corneal transplant for keratoconus. Within four days she developed a graft rejection that required a penetrating keratoplasty two years later. Six months later, after hepatitis B immunization, the patient reported decreased vision and the graft was cloudy, but visual acuity was 20 20. The other four patients developed graft rejection after influenza immunization. Two of these four graft rejection episodes were successfully treated with high-dose corticosteroid therapy; all episodes occurred within several weeks of influenza immunization. Patients should be prudently counseled regarding the possible risks of immunization to corneal allograft survival.

Original languageEnglish
Pages (from-to)575-578
Number of pages4
JournalAmerican Journal of Ophthalmology
Issue number5
StatePublished - Nov 15 1988

ASJC Scopus subject areas

  • Ophthalmology


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