Coronary Microvascular Dysfunction in Patients with Non-Obstructive Coronary Arteries: Current Gaps and Future Directions

Islam Y. Elgendy; Lina Ya’Qoub; Kuan Han Chen; Carl J. Pepine

doi:10.1007/s40265-021-01667-y

Coronary Microvascular Dysfunction in Patients with Non-Obstructive Coronary Arteries: Current Gaps and Future Directions

Islam Y. Elgendy
, Lina Ya’Qoub
, Kuan Han Chen
, Carl J. Pepine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

There has been increasing interest in open artery syndrome, also known as ischemia with non-obstructive coronary arteries (INOCA). INOCA has been increasingly recognized as a heterogeneous clinical entity. Diagnostic evaluation of this heterogeneous entity, including invasive assessment, remains key to diagnose this clinical condition and provide the appropriate treatment. Importantly, medical stratification based on the type of INOCA has shown benefit in improving the symptoms in these patients, as illustrated in the CorMicA trial. The Women’s IschemiA Trial to Reduce Events in Non-ObstRuctIve CORonary Artery Disease (WARRIOR) is another promising landmark trial that is currently enrolling patients and will address some of the unanswered questions for management of women with INOCA. In this review, we discuss the pathophysiology, management options, knowledge gaps, and future directions while highlighting the rationale and design of the ongoing WARRIOR trial.

Original language	English
Pages (from-to)	241-250
Number of pages	10
Journal	Drugs
Volume	82
Issue number	3
DOIs	https://doi.org/10.1007/s40265-021-01667-y
State	Published - Feb 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Funding

Unrelated to this manuscript content, Dr. Elgendy has received research grants from Caladrius Biosciences, Inc. Drs Ya’Qoub, Chen and Pepine declare that they have no potential conflicts of interest that might be relevant to the contents of this manuscript.

Funders
Caladrius Biosciences Inc

ASJC Scopus subject areas

Pharmacology (medical)

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10.1007/s40265-021-01667-y

Cite this

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title = "Coronary Microvascular Dysfunction in Patients with Non-Obstructive Coronary Arteries: Current Gaps and Future Directions",

abstract = "There has been increasing interest in open artery syndrome, also known as ischemia with non-obstructive coronary arteries (INOCA). INOCA has been increasingly recognized as a heterogeneous clinical entity. Diagnostic evaluation of this heterogeneous entity, including invasive assessment, remains key to diagnose this clinical condition and provide the appropriate treatment. Importantly, medical stratification based on the type of INOCA has shown benefit in improving the symptoms in these patients, as illustrated in the CorMicA trial. The Women{\textquoteright}s IschemiA Trial to Reduce Events in Non-ObstRuctIve CORonary Artery Disease (WARRIOR) is another promising landmark trial that is currently enrolling patients and will address some of the unanswered questions for management of women with INOCA. In this review, we discuss the pathophysiology, management options, knowledge gaps, and future directions while highlighting the rationale and design of the ongoing WARRIOR trial.",

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Coronary Microvascular Dysfunction in Patients with Non-Obstructive Coronary Arteries: Current Gaps and Future Directions

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

Access to Document

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