TY - JOUR
T1 - Coronavirus disease 2019 in children
T2 - Characteristics, antimicrobial treatment, and outcomes
AU - Peng, Hui
AU - Gao, Ping
AU - Xu, Qiong
AU - Liu, Maochang
AU - Peng, Jing
AU - Wang, Yang
AU - Xu, Hua
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/7
Y1 - 2020/7
N2 - Background: At present, coronavirus disease 2019 (COVID-19) has spread in many countries. We conducted this study to help pediatricians understand the conditions of COVID-19 in children. Methods: We retrospectively summarized the characteristics, treatment and outcomes of pediatric cases in Wuhan Children's Hospital which was the only designated hospital for children with COVID-19 in Hubei Province. A Cox proportional hazards regression analysis was used to evaluate factors associated with clinical outcomes. Results: As of February 29, 75 children had been discharged, of which only one was has severe pneumonia and one was critical cases. Children younger than 2 years were more susceptible to COVID-19. All patients have received interferon-α nebulization, and eight cases including the severe and critical cases were co-administrated ribavirin. Five patients with mild pneumonia were given arbidol. Twenty-three patients were given traditional Chinese medicine (TCM). The average length of stay (LOS) and the time of SARS-CoV-2 clearance were 10.57 and 6.39 days, respectively. None of the factors was associated with LOS or time of SARS-CoV-2 clearance. Conclusions: The severity of COVID-19 in pediatric cases were milder than adults. The efficacy of the antiviral therapy in children with COVID-19 remains to be evaluated.
AB - Background: At present, coronavirus disease 2019 (COVID-19) has spread in many countries. We conducted this study to help pediatricians understand the conditions of COVID-19 in children. Methods: We retrospectively summarized the characteristics, treatment and outcomes of pediatric cases in Wuhan Children's Hospital which was the only designated hospital for children with COVID-19 in Hubei Province. A Cox proportional hazards regression analysis was used to evaluate factors associated with clinical outcomes. Results: As of February 29, 75 children had been discharged, of which only one was has severe pneumonia and one was critical cases. Children younger than 2 years were more susceptible to COVID-19. All patients have received interferon-α nebulization, and eight cases including the severe and critical cases were co-administrated ribavirin. Five patients with mild pneumonia were given arbidol. Twenty-three patients were given traditional Chinese medicine (TCM). The average length of stay (LOS) and the time of SARS-CoV-2 clearance were 10.57 and 6.39 days, respectively. None of the factors was associated with LOS or time of SARS-CoV-2 clearance. Conclusions: The severity of COVID-19 in pediatric cases were milder than adults. The efficacy of the antiviral therapy in children with COVID-19 remains to be evaluated.
KW - Characteristics
KW - Coronavirus disease 2019
KW - Outcomes
KW - Pediatric
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=85084862224&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85084862224&partnerID=8YFLogxK
U2 - 10.1016/j.jcv.2020.104425
DO - 10.1016/j.jcv.2020.104425
M3 - Article
C2 - 32446167
AN - SCOPUS:85084862224
SN - 1386-6532
VL - 128
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
M1 - 104425
ER -